Prognostic impact of soluble intercellular adhesion molecule-1 in hepatocellular carcinoma

被引：10

作者：

Shimura, Tatsuo ^{[1
]}

Shibata, Masahiko ^{[2
]}

Gonda, Kenji ^{[2
]}

Kofunato, Yasuhide ^{[1
]}

Ishigame, Teruhide ^{[1
]}

Okada, Ryo ^{[1
]}

Sato, Naoya ^{[1
]}

Kimura, Takashi ^{[1
]}

Kenjo, Akira ^{[1
]}

Marubashi, Shigeru ^{[1
]}

机构：

[1] Fukushima Med Univ, Dept Hepatobiliary Pancreat & Transplant Surg, 1 Hikarigaoka, Fukushima 9601259, Japan

[2] Fukushima Med Univ, Dept Gastrointestinal Tract Surg, Fukushima 9601259, Japan

来源：

ONCOLOGY LETTERS | 2018年 / 16卷 / 05期

基金：

日本学术振兴会;

关键词：

hepatocellular carcinoma; intercellular adhesion molecule-1; overall survival; recurrence-free survival; prognosis; SERUM-LEVELS; DIFFERENTIAL EXPRESSION; DISEASE PROGRESSION; LIVER RESECTION; E-SELECTIN; ICAM-1; CELLS; CD54; ANTIGENS; OUTCOMES;

D O I：

10.3892/ol.2018.9367

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The identification of novel biomarkers for hepatocellular carcinoma (HCC) is of great importance in improving the outcome of patients with HCC. The present study aimed to determine the prognostic significance of the soluble intercellular adhesion molecule (sICAM)-1 in patients with HCC. The present study prospectively collected clinicopathological data from 36 patients with HCC who had undergone successful hepatectomy. An analysis using a receiver operating characteristic (ROC) curve was performed to determine the cut-off value for predicting prognosis. Overall survival (OS), recurrence-free survival (RFS) and potential prognostic factors were analyzed. The ROC curve analysis revealed a sICAM-1 cut-off value of 440 ng/ml. HCC patients with sICAM-1 440 ng/ml exhibited a poorer OS and RFS than those with sICAM-1 <440 ng/ml (P=0.002). sICAM-1 440 ng/ml (hazard ratio=3.623; 95% confidence interval: 1.145-11.458; P=0.028) and Child B (hazard ratio=1.514; 95% confidence interval: 1.066-2.150; P=0.021) were independent prognostic factors for OS, and sICAM-1 440 ng/ml was an independent prognostic factor for RFS (hazard ratio=3.625; 95% confidence interval: 1.233-10.659; P=0.019). Serum sICAM-1 may be a promising predictor for the overall and recurrence-free survival of patients with HCC.

引用

页码：6013 / 6018

页数：6