Inclusion Complex of Isoliquiritigenin With Sulfobutyl Ether-β-Cyclodextrin: Preparation, Characterization, Inclusion Mode, Solubilization, and Stability

Isoliquiritigenin (ISL) possesses a wide variety of pharmacological properties, however, its poor solubility and oral bioavailability pose a significant barrier to its application. In present studies, the ISL inclusion complex was prepared with sulfobutyl ether-beta-cyclodextrin (SBE-beta-CD). The physicochemical characterizations of ISL-SBE-beta-CD were performed with Fourier transform infrared (FT-IR) spectroscopy and X-ray powder diffraction (XRD). Phase solubility study suggested a 1:1 formation of ISL-SBE-beta-CD complexes. The water solubility of ISL rose from 13.6 mu M to 4.05 mM by the inclusion of SBE-beta-CD. The antioxidant activities (IC50) of ISL-SBE-beta-CD reached 42.2 mu g/ml, which was significantly lower than that of ISL (60.5 mu g/ml). Its stability in biological environments was also enhanced.