Rapid and indirect inhibition of organic anion transporting polypeptide (OATP) 1B1 transport activity by lysosomotropic drug chloroquine: implications in OATP-mediated drug-drug interactions

被引：0
|
作者：
Alam, Khondoker [1 ]
Abuznait, Alaa [1 ]
Pahwa, Sonia [1 ]
Wang, Xueying [2 ]
Zhang, Pengyue [2 ]
Ding, Kai [3 ]
Li, Lang [2 ]
Yue, Wei [1 ]
机构：
[1] Univ Oklahoma, Hlth Sci Ctr, Coll Pharm, Pharmaceut Sci, Oklahoma City, OK 73190 USA
[2] Indiana Univ Sch Med, Ctr Computat Biol & Bioinformat, Indianapolis, IN 46202 USA
[3] Univ Oklahoma, Hlth Sci Ctr, Dept Biostat & Epidemiol, Oklahoma City, OK USA
来源：
DRUG METABOLISM REVIEWS | 2016年 / 48卷
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
P268
引用
收藏
页码：152 / 152
页数：1
相关论文
共 50 条
  • [1] Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug Interactions
    Alam, Khondoker
    Pahwa, Sonia
    Wang, Xueying
    Zhang, Pengyue
    Ding, Kai
    Abuznait, Alaa H.
    Li, Lang
    Yue, Wei
    MOLECULAR PHARMACEUTICS, 2016, 13 (03) : 839 - 851
  • [2] Regulation of Organic Anion Transporting Polypeptides (OATP) 1B1-and OATP1B3-Mediated Transport: An Updated Review in the Context of OATP-Mediated Drug-Drug Interactions
    Alam, Khondoker
    Crowe, Alexandra
    Wang, Xueying
    Zhang, Pengyue
    Ding, Kai
    Li, Lang
    Yue, Wei
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (03)
  • [3] IMPAIRED OATP1B1-MEDIATED TRANSPORT FOLLOWING TREATMENT WITH LYSOSOMOTROPIC DRUG CHLOROQUINE: IMPLICATIONS IN OATP-MEDIATED DRUGeDRUG INTERACTIONS
    Yue, Wei
    DRUG METABOLISM AND PHARMACOKINETICS, 2018, 33 (01) : S12 - S12
  • [4] Contribution of organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 to hepatic uptake of nateglinide, and the prediction of drug-drug interactions via these transporters
    Takanohashi, Toshiyuki
    Kubo, Satoru
    Arisaka, Harumi
    Shinkai, Kenji
    Ubukata, Kazuyuki
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2012, 64 (02) : 199 - 206
  • [5] Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia
    Campbell, SD
    de Morais, SM
    Xu, JHJ
    CHEMICO-BIOLOGICAL INTERACTIONS, 2004, 150 (02) : 179 - 187
  • [6] Generation of Bayesian prediction models for OATP-mediated drug-drug interactions based on inhibition screen of OATP1B1, OATP1B1*15 and OATP1B3
    van de Steeg, E.
    Venhorst, J.
    Jansen, H. T.
    Nooijen, I. H. G.
    DeGroot, J.
    Wortelboer, H. M.
    Vlaming, M. L. H.
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2015, 70 : 29 - 36
  • [7] Preincubation With Everolimus and Sirolimus Reduces Organic Anion-Transporting Polypeptide (OATP)1B1-and 1B3-Mediated Transport Independently of mTOR Kinase Inhibition: Implication in Assessing OATP1B1-and OATP1B3-Mediated Drug-Drug Interactions
    Farasyn, Taleah
    Crowe, Alexandra
    Hatley, Oliver
    Neuhoff, Sibylle
    Alam, Khondoker
    Kanyo, Jean
    Lam, TuKiet T.
    Ding, Kai
    Yue, Wei
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 108 (10) : 3443 - 3456
  • [8] Preincubation-dependent and long-lasting inhibition of organic anion transporting polypeptide (OATP) and its impact on drug-drug interactions
    Shitara, Yoshihisa
    Sugiyama, Yuichi
    PHARMACOLOGY & THERAPEUTICS, 2017, 177 : 67 - 80
  • [9] Investigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug Interactions
    Izumi, Saki
    Nozaki, Yoshitane
    Maeda, Kazuya
    Komori, Takafumi
    Takenaka, Osamu
    Kusuhara, Hiroyuki
    Sugiyama, Yuichi
    DRUG METABOLISM AND DISPOSITION, 2015, 43 (02) : 235 - 247
  • [10] Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3
    Noe, Johannes
    Portmann, Renee
    Brun, Marie-Elise
    Funk, Christoph
    DRUG METABOLISM AND DISPOSITION, 2007, 35 (08) : 1308 - 1314
12345