Solid-Liquid Phase Equilibrium and Thermodynamic Properties of Olaparib in Selected Organic Solvents and (Tetrahydrofuran plus MTBE, Acetonitrile plus Isopropyl Alcohol) Binary Solvent Mixtures

We focused on the solubility of olaparib under atmospheric pressure in isopropyl alcohol, MTBE, acetonitrile, and tetrahydrofuran as well as in the (tetrahydrofuran + MTBE, acetonitrile + isopropyl alcohol) mixtures from 280.35-319.35 K. It is found that the solubility of olaparib and temperature were positively correlated in the range of our study. We chose the modified Apelblat equation, the Buchowski-Ksiazaczak lambda h equation, CNIBS/R-K equation, and the Jouyban-Acree equation to verify the thermodynamic properties of olaparib. Computational results showed that all selected equations agreed well with the experimental data, and the modified Apelblat equation gives the best correlation. We also selected two binary solvent dissolution systems, and the test found that (tetrahydrofuran + MTBE) mixtures may be a good recrystallization system. This study provides valuable data for olaparib's production process purification.