Contributions of endothelin-1 and L-arginine to blunted cutaneous microvascular function in young, black women

被引:7
|
作者
Akins, John D. [1 ]
Richey, Rauchelle E. [1 ,2 ]
Campbell, Jeremiah C. [1 ]
Martin, Zachary T. [1 ]
Olvera, Guillermo [1 ,3 ]
Brothers, R. Matthew [1 ]
机构
[1] Univ Texas Arlington, Dept Kinesiol, Arlington, TX 76019 USA
[2] Univ North Texas, Hlth Sci Ctr Ft Worth, Dept Integrat Physiol, Ft Worth, TX USA
[3] Inst Exercise & Environm Med, Dallas, TX USA
关键词
cardiovascular disease; endothelin-1; L-arginine; non-Hispanic black women; vascular function; NITRIC-OXIDE; RACIAL-DIFFERENCES; BLOOD-PRESSURE; RECEPTOR CONTRIBUTION; VASODILATION; DYSFUNCTION; AUGMENTS; TETRAHYDROBIOPTERIN; ARGINASE; EXPRESSION;
D O I
10.1152/ajpheart.00457.2021
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Non-Hispanic black (BL) individuals have the greatest prevalence of cardiovascular disease (CVD), relative to other racial/ethnic groups (e.g., non-Hispanic white population; WH), which may be secondary to blunted vascular function. Although women typically present with reduced CVD relative to men of the same racial/ethnic group, the prevalence is similar between BL women and men though the mechanisms differ. This study hypothesized that reduced microvascular function in young, BL women is associated with endothelin-1 (ET-1) overactivity or insufficient L-arginine bioavailability. Nine BL and nine WH women participated (age: 20 +/- 2 vs. 22 +/- 2 yr). Cutaneous microvascular function was assessed during 39 degrees C local heating, whereas lactated Ringer's (control), BO-123 (ET-1 receptor type A antagonist), BO-788 (ET-1 receptor type B antagonist), or L-arginine were infused via intradermal microdialysis to modify cutaneous vascular conductance (CVC). Subsequent infusion of N-omega-nitro-L-arginine methyl ester allowed for quantification of the nitric oxide (NO) contribution to vasodilation, whereas combined sodium nitroprusside and 43 degrees C heating allowed for normalization to maximal CVC (%CVCmax). BL women had blunted %CVCmax and NO contribution to dilation during the 39 degrees C plateau (P < 0.027 for both). B0-123 improved this response through augmented NO-mediated dilation (P < 0.048 for both). B0-788 and L-arginine did not alter the CVC responses (P > 0.835 for both) or the NO contribution (P > 0.371 for both). Cutaneous microvascular function is reduced in BL women, and ET-1 receptor type A may contribute to this reduced function. Further research is needed to better characterize these mechanisms in young, BL women. NEW & NOTEWORTHY Cardiovascular disease remains a burden in the United States non-Hispanic black (BL) population, although its manifestation through blunted vasodilation in this population is different between men and women. Accordingly, this study determined that reduced microvascular function in young, BL women may be partially controlled by endothelin-1 (ET-1) type A receptors, although neither type B receptors nor insufficient L-arginine bioavailability seems to contribute to this response. Accordingly, further research is needed to better characterize these ET-1 related mechanisms and illuminate other pathways that may contribute to this disparate vascular function in young, BL women.
引用
收藏
页码:H260 / H268
页数:9
相关论文
共 50 条
  • [1] Blunted Cutaneous Thermal Reactivity in Black Women and the Relationship with Endothelin-1 and L-arginine
    Akins, John
    Richey, Rauchelle
    Campbell, Jeremiah
    Martin, Zachary
    Brothers, R.
    FASEB JOURNAL, 2020, 34
  • [2] Blunted Sensory Nerve-Mediated Cutaneous Vasodilation in Black Women and the Relationship with Endothelin-1 and L-arginine
    Campbell, Jeremiah
    Akins, John
    Richey, Rauchelle
    Patik, Jordan
    Martin, Zachary
    Brothers, R.
    FASEB JOURNAL, 2021, 35
  • [3] Sex differences in the mechanisms mediating blunted cutaneous microvascular function in young black men and women
    Patik, Jordan C.
    Curtis, Bryon M.
    Nasirian, Aida
    Vranish, Jennifer R.
    Fadel, Paul J.
    Brothers, R. Matthew
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2018, 315 (04): : H1063 - H1071
  • [4] Endothelin-1 and L-Arginine in Preterm Infants with Respiratory Distress
    El Sayed, Manal
    Sherif, Lobna
    Said, Reem N.
    El-Wakkad, Amany S. E.
    El-Refay, Amira
    Aly, Hany
    AMERICAN JOURNAL OF PERINATOLOGY, 2011, 28 (02) : 129 - 135
  • [5] Attenuated cutaneous microvascular function in healthy young African Americans: Role of intradermal L-arginine supplementation
    Kim, Kiyoung
    Hurr, Chansol
    Patik, Jordan C.
    Brothers, R. Matthew
    MICROVASCULAR RESEARCH, 2018, 118 : 1 - 6
  • [6] EFFECTS OF ENDOTHELIN-1 (ET-1) AND L-ARGININE (L-ARG) ON RENAL-FUNCTION IN MAN
    RABELINK, AJ
    BIJLSMA, JA
    STROES, E
    KOOMANS, HA
    KIDNEY INTERNATIONAL, 1995, 47 (02) : 666 - 666
  • [7] Effects of endothelin-1 and L-arginine after cold ischemia in lamb hearts
    Hiramatsu, T
    Forbess, JM
    Miura, T
    Roth, SJ
    Cioffi, MA
    Mayer, JE
    ANNALS OF THORACIC SURGERY, 1996, 61 (01): : 36 - 40
  • [8] Ascorbic acid or L-arginine improves cutaneous microvascular function in chronic kidney disease
    DuPont, Jennifer J.
    Farquhar, William B.
    Townsend, Raymond R.
    Edwards, David G.
    JOURNAL OF APPLIED PHYSIOLOGY, 2011, 111 (06) : 1561 - 1567
  • [9] Effects of endothelin-1 and L-arginine after cold ischemia in lamb hearts - Discussion
    He, GW
    Hammon, JW
    Hiramatsu, T
    Levitsky, S
    Mayer, JM
    ANNALS OF THORACIC SURGERY, 1996, 61 (01): : 40 - 41
  • [10] L-arginine as dietary supplement for improving microvascular function
    Melik, Ziva
    Zaletel, Polona
    Virtic, Tina
    Cankar, Ksenija
    CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 2017, 65 (03) : 205 - 217