Memory-enhancing effect of Rhodiola rosea L extract on aged mice

被引：3

作者：

Cao, Yanjing ^{[1
,2
,3
]}

Liang, Lizhen ^{[2
,3
]}

Xu, Jian ^{[5
]}

Wu, Jiali ^{[2
,3
]}

Yan, Yongxing ^{[2
,3
]}

Lin, Ping ^{[2
,3
]}

Chen, Qiang ^{[2
,3
]}

Zheng, Fengming ^{[2
,3
]}

Wang, Qin ^{[2
,3
]}

Ren, Qian ^{[2
,3
]}

Gou, Zengmei ^{[6
]}

Fan, Yongjun ^{[4
]}

Du, Yifeng ^{[1
]}

机构：

[1] Shandong Univ, Shandong Prov Hosp, Dept Neurol, Jinan 250013, Shandong, Peoples R China

[2] AnHui Med Univ, Peoples Hosp HangZhou 3, Dept Neurol, Hangzhou 310009, Zhejiang, Peoples R China

[3] AnHui Med Univ, Hosp 3, Hangzhou 310009, Zhejiang, Peoples R China

[4] Griffith Univ, Eskitis Inst Drug Discovery, Brisbane, Qld 4111, Australia

[5] ZheJiang Chinese Med Univ, Dept Histol & Embryol, Hangzhou 310053, Zhejiang, Peoples R China

[6] Second Peoples Hosp WeiFang, Dept Neurol, Weifang 261041, Shandong, Peoples R China

来源：

TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH | 2016年 / 15卷 / 07期

关键词：

Rhodiola rosea; Memory function; Catalase; Acetyl cholinesterase; Open-field test; ALZHEIMERS-DISEASE; BRAIN; ACETYLCHOLINESTERASE;

D O I：

10.4314/tjpr.v15i7.14

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Purpose: The memory-enhancing effects of Rhodiola rosea L. extract (RRLE) on normal aged mice were assessed. Methods: In the open-field test, the effect of RRLE (150 and 300 mg/kg) on mouse locomotive activities was evaluated by investigating the extract's influence on CAT and AchE activities in the brain tissue of mice. Results: Compared with aged group, high dose of RRLE reduced the total distance (3212.4 +/- 123.1 cm, p < 0.05) significantly, increased catalase (CAT) activity (101.4 +/- 12.2 U/mg pro, p < 0.05), and inhibited acetyl cholinesterase (AChE) activity (0.94 +/- 0.12 U/mg pro, p < 0.05) in the brain tissue of aged mice. Conclusion: The results show that RRLE improves the memory functions of aged mice probably by increasing CAT activity while decreasing AChE activity.

引用

页码：1453 / 1457

页数：5

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