Probing Indole Diketopiperazine-Based Hybrids as Environmental-Induced Products from Aspergillus sp. EGF 15-0-3

被引：24

作者：

Wei, Xia ^{[1
]}

Su, Jun-Cheng ^{[2
]}

Hu, Jin-Shan ^{[1
]}

He, Xi-Xin ^{[1
]}

Lin, Shuang-Jun ^{[2
]}

Zhang, Dong-Mei ^{[3
]}

Ye, Wen-Cai ^{[3
]}

Chen, Min-Feng ^{[3
]}

Lin, Hou-Wen ^{[2
]}

Zhang, Cui-Xian ^{[1
]}

机构：

[1] Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China

[2] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Pharm,State Key Lab Oncogenes & Related Gene, Shanghai 200127, Peoples R China

[3] Jinan Univ, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Peoples R China

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 01期

基金：

中国国家自然科学基金;

关键词：

ALKALOIDS; FUNGUS;

D O I：

10.1021/acs.orglett.1c03795

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Comprehensive analyses of the metabolite spectra of Aspergillus sp. EGF 15-0-3 under different culture conditions revealed the presence of unique environmental-induced metabolites exclusively from the rice medium. Subsequent target isolation afforded four unprecedented indole diketopiperazine-based hybrids with a pyrano[3',2': 7,8]isochromeno[4,3-b]pyrazino[2,1-i]indole core (1 and 2) or a spiro[piperazine-2,2'-pyrano[3,4,5-de]chromene] scaffold (3 and 4). Putative biosynthetic pathways for 1-4, with Diels-Alder cycloadditions as key steps, were proposed. 1-4 exhibited selective cytotoxicities among several human cancer cells.

引用

页码：158 / 163

页数：6

共 4 条

[1] New Indole Diketopiperazine Alkaloids from Soft Coral-Associated Epiphytic Fungus Aspergillus sp. EGF 15-0-3
Wei, Xia
Feng, Chan
Wang, Si-Yu
Zhang, Dong-Mei
Li, Xiao-Hui
Zhang, Cui-Xian
CHEMISTRY & BIODIVERSITY, 2020, 17 (05)
[2] New Benzaldehyde Derivatives From the Soft Coral-Associated Epiphytic Fungus Aspergillus Sp. EGF 15-0-3
Zhang, Ze-Kun
Li, Ze-Jun
Guo, Li-Shuang
Duan, Xue-Wei
Liu, Bing-Bing
An, Lin-Kun
He, Xi-Xin
Zhang, Cui-Xian
CHEMISTRY & BIODIVERSITY, 2025,
[3] Pyranodipyran Derivatives with Tyrosyl DNA Phosphodiesterase 1 Inhibitory Activities and Fluorescent Properties from Aspergillus sp. EGF 15-0-3
Wei, Xia
Wang, Fang-Ting
Si-Tu, Mei-Xia
Fan, Hao
Hu, Jin-Shan
Yang, Hao
Guan, Shan-Yue
An, Lin-Kun
Zhang, Cui-Xian
MARINE DRUGS, 2022, 20 (03)
[4] Researches on the Subergane-Type Sesquiterpenes from the Soft Coral-Derived Fungus Aspergillus sp. EGF15-0-3
Feng, Chan
Wei, Xia
Hu, Jinshan
Wang, Siyu
Liu, Bingxin
Xie, Zhenyu
Rong, Li
Li, Xiaohui
Zhang, Cuixian
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 40 (05) : 1275 - 1280

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