Synthesis, characterization, and biological and anticancer studies of mixed ligand complexes with Schiff base and 2,2′-bipyridine

被引：54
|
作者：
Omar, M. M. [1 ]
Abd El-Halim, Hanan F. [2 ]
Khalil, Eman A. M. [3 ]
机构：
[1] Cairo Univ, Chem Dept, Fac Sci, Giza 12613, Egypt
[2] Misr Int Univ, Pharmaceut Chem Dept, Fac Pharm, Cairo, Egypt
[3] Modern Univ Technol & Informat, Fac Phys Therapy, Cairo, Egypt
来源：
APPLIED ORGANOMETALLIC CHEMISTRY | 2017年 / 31卷 / 10期
关键词：
2,2 '-bipyridine; anticancer activity; biological activity; mixed ligand complexes; Schiff base ligand; TRANSITION-METAL-COMPLEXES; STRUCTURAL-CHARACTERIZATION; COORDINATION BEHAVIOR; ZINC(II) COMPLEXES; CU(II); NI(II); ANTIBACTERIAL; ZN(II); COPPER(II); CO(II);
D O I：
10.1002/aoc.3724
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
New mixed ligand complexes of transition metals were synthesized from a Schiff base (L-1) obtained by the condensation reaction of oxamide and furfural as primary ligand and 2,2 '-bipyridine (L-2) as secondary ligand. The ligands and their metal complexes were studied using various spectroscopic methods. Also thermal analyses were conducted. The mixed ligand complexes were found to have formulae [M(L-1) (L-2)] Cl-m center dot nH(2)O (M = Cr(III) and Fe(III): m = 3, n = 0; M = Cu(II) and Cd(II): m = 2, n = 1; M = Mn(II), Co(II), Ni(II) and Zn(II): m = 2, n = 0). The resultant data revealed that the metal complexes have octahedral structure. Also, the mixed ligand complexes are electrolytic. The biological and anticancer activities of the new compounds were tested against breast cancer (MCF-7) and colon cancer (HCT-116) cell lines. The results showed high activity for the synthesized compounds.
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页数：11
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