In vivo tracking of TDP43 in ALS: cognition as a new biomarker for brain pathology

被引:5
|
作者
Lule, Dorothee E. [1 ]
Ludolph, Albert C. [2 ]
机构
[1] Univ Ulm, Dept Neurol, Neuropsychol, Ulm, Germany
[2] Univ Ulm, Dept Neurol, Ulm, Germany
来源
关键词
ALS; cognition; neuropsychology; post mortem; motor neuron disease;
D O I
10.1136/jnnp-2019-321940
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
引用
收藏
页码:125 / 125
页数:1
相关论文
共 50 条
  • [1] Shortened TDP43 isoforms upregulated by neurona hyperactivity drive TDP43 pathology in ALS
    Weskamp, Kaitlin
    Tank, Elizabeth M.
    Miguez, Roberto
    McBride, Jonathon P.
    Gomez, Nicolas B.
    White, Matthew
    Lin, Ziqiang
    Gonzalez, Carmen Moreno
    Serio, Andrea
    Sreedharan, Jemeen
    Barmada, Sami J.
    JOURNAL OF CLINICAL INVESTIGATION, 2020, 130 (03): : 1139 - 1155
  • [2] Dementia phenotypes associated with TDP43 versus mixed TDP43/Alzheimer pathology
    Kansal, Kalyani
    Irwin, David
    Pletnikova, Olga
    Trojanowski, John
    Rabins, Peter
    Troncoso, Juan
    Grossman, Murray
    Onyike, Chiadi
    INTERNATIONAL PSYCHOGERIATRICS, 2015, 27 : S116 - S117
  • [3] Novel small molecule therapeutics for ALS reduce TDP43 and beta amyloid related pathology in vitro and in vivo
    Mathur, Vidhu
    Kokes, Marcela
    Shao, Eric
    Arya, Shruti
    van Hummel, Annika
    Sabale, Miheer
    Ke, Yazi
    Burk, Kevin
    Singh, Ambuj
    Planey, Katie
    MUSCLE & NERVE, 2023, 68 : S4 - S5
  • [4] Extraction of Enriched Phosphorylated TDP43 from ALS Tissue for Evaluation of New TDP-43 Radiotracers
    Tanzey, Sean
    Brooks, Allen
    Shao, Xia
    Scott, Peter
    JOURNAL OF NUCLEAR MEDICINE, 2020, 61
  • [5] TDP43 pathology in chronic traumatic encephalopathy retinas
    Ragini Phansalkar
    Vanessa S. Goodwill
    Jeffrey J. Nirschl
    Chiara De Lillo
    Jihee Choi
    Elizabeth Spurlock
    David G. Coughlin
    Donald Pizzo
    Christina J. Sigurdson
    Annie Hiniker
    Victor E. Alvarez
    Ann C. Mckee
    Jonathan H. Lin
    Acta Neuropathologica Communications, 11
  • [6] APOE*ε4 — a risk factor for TDP43 pathology?
    Ian Fyfe
    Nature Reviews Neurology, 2018, 14 : 570 - 571
  • [7] TDP-43 pathology and cognition in ALS: A prospective clinicopathologic correlation study
    Prudlo, Johannes
    Koenig, Jochem
    Schuster, Christina
    Kasper, Elisabeth
    Buettner, Andreas
    Teipel, Stefan
    Neumann, Manuela
    NEUROLOGY, 2016, 87 (10) : 1019 - 1023
  • [8] Alternative TDP43 Isoforms Underlying Neurodegeneration in ALS and FTD
    Dykstra, Megan
    Tank, Elizabeth
    Barmada, Sami
    ANNALS OF NEUROLOGY, 2022, 92 : S156 - S156
  • [9] TDP43 pathology in chronic traumatic encephalopathy retinas
    Phansalkar, Ragini
    Goodwill, Vanessa S.
    Nirschl, Jeffrey J.
    De Lillo, Chiara
    Choi, Jihee
    Spurlock, Elizabeth
    Coughlin, David G.
    Pizzo, Donald
    Sigurdson, Christina J.
    Hiniker, Annie
    Alvarez, Victor E.
    Mckee, Ann C.
    Lin, Jonathan H.
    ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2023, 11 (01)
  • [10] TDP43: A Focal Point for RNA Therapeutics in ALS/FTD
    Barmada, Sami
    ANNALS OF NEUROLOGY, 2024, 96 : S300 - S300