Preparation of 4(3H)-quinazolinones from aryldiazonium salt, nitriles and 2-aminobenzoate via a cascade annulation

被引：16

作者：

Ramanathan, Mani ^{[1
]}

Hsu, Ming-Tsung ^{[1
]}

Liu, Shiuh-Tzung ^{[1
]}

机构：

[1] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

来源：

TETRAHEDRON | 2019年 / 75卷 / 06期

关键词：

Quinazolinone; Diazonium; Nitrilium; Nitrile; Annulation; CHEMISTRY; QUINAZOLINONES; AFLOQUALONE; INHIBITORS; POTENT;

D O I：

10.1016/j.tet.2018.12.065

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

One-pot synthesis of 3-aryl-4(3H)-quinazolinones has been realized through a cascade annulation. Reaction of aryldiazonium salt with a nitrile provides in situ generation of a reactive nitrilium ion, which is attacked by the amino group of 2-aminobenzoate followed by cyclization to deliver the desired product. This strategy offers a convenient and easy access to a wide range of functionalized quinazolinone. (C) 2018 Published by Elsevier Ltd.

引用

页码：791 / 796

页数：6

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