Synthesis, crystal structure, theoretical calculations and antimicrobial properties of [Pt(tetramethylthiourea)4] [Pt(CN)4]•4H2O

A new platinum(II) complex, [Pt(Tmtu)(4)][Pt(CN)(4)]center dot 4H(2)O (1) was synthesized by reaction of K-2[PtCl4], KCN and tetramethylthiourea (Tmtu). Its structure was determined by X-ray crystallography. The [Pt(CN)(4)](2-) anion shows regular square planar geometry at platinum, while in the [Pt(Tmtu)(4)](2+) cation the geometry at platinum is somewhat distorted. Hydrogen bonding between water molecules and the cyanide nitrogen of [Pt(CN)(4)](2-) ions stabilizes the structure and leads to a supramolecular 2D network. DFT calculations support the experimentally found dinuclear (homocoordinated) ion-pair structure 1 as the most stable in comparison to noncovalent dimer [Pt(CN)(2)(Tmtu)(2)](2) 2(2) that could, in turn, be involved in the formation sequence of I. Antimicrobial activities of the complex were evaluated by minimum inhibitory concentration and the results showed that the complex exhibited moderate activities against gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and molds (Aspergillus niger, Penicillium citrinum). (C) 2015 Elsevier B.V. All rights reserved.