Anti-tumor promoting effects of multiflorane-type triterpenoids and cytotoxic activity of karounidiol against human cancer cell lines

被引：53
|
作者：
Akihisa, T
Tokuda, H
Ichiishi, E
Mukainaka, T
Toriumi, M
Ukiya, M
Yasukawa, K
Nishino, H
机构：
[1] Nihon Univ, Coll Sci & Technol, Chiyoda Ku, Tokyo 1018308, Japan
[2] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan
[3] Nihon Univ, Coll Pharm, Funabashi, Chiba 2748555, Japan
来源：
CANCER LETTERS | 2001年 / 173卷 / 01期
关键词：
Trichosanthes kirilowii; Cucurbitaceae; anti-tumor promoter; Epstein-Barr virus early antigens; multiflorane-type triterpenoids; structure-activity relationships; cytotoxicity;
D O I：
10.1016/S0304-3835(01)00689-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Forty-nine multiflorane-type triterpenoids consisting of 11 compounds isolated from the seeds of Trichosanthes kirilowii (Cucurbitaceae) and 38 of their derivatives have been evaluated for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in Raji cells as a primary screening test for anti-tumor promoters. All of the compounds tested showed an inhibitory effect against EBV-EA activation, and among which 43 were revealed to possess remarkable activity with potencies either comparable to or stronger than that of glycyrrhetic acid, a known natural anti-tumor promoter. Their structure-activity relationship is discussed. Evaluation of the cytotoxic activity of karounidiol (27) against human cancer cell lines exhibited cytotoxicity especially against a human renal cancer. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：9 / 14
页数：6
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