Improvement of electrochemical detection of transthyretin synthetic peptide and its amino acids on carbon electrodes: Glassy carbon versus amorphous carbon nitride a-CNx

被引:9
|
作者
Faure, M. [1 ]
Billon, F. [1 ]
Le Potier, I. [2 ]
Haghiri-Gosnet, A. -M. [2 ]
Tribollet, B. [1 ]
Pailleret, A. [1 ]
Deslouis, C. [1 ]
Gamby, J. [1 ,2 ]
机构
[1] Sorbonne Univ, CNRS, LISE, UMR 8235, 4 Pl Jussieu, F-75005 Paris, France
[2] Univ Paris Saclay, Univ Paris Sud, CNRS, Ctr Nanosci & Nanotechnol, Ave Vauve, F-91120 Palaiseau, France
关键词
Transthyretin peptide; Amorphous carbon nitride; Impedance spectroscopy; Cyclic voltammetry; Differential pulse voltammetry; MOLECULAR IMPRINTING POLYMER; BORON-DOPED DIAMOND; HEAVY-METALS; THIN-FILMS; REACTIVITY; NANOTUBES; NAPHTHALENE-2,3-DICARBOXALDEHYDE; ELECTROPHORESIS; DERIVATIZATION; VOLTAMMETRY;
D O I
10.1016/j.electacta.2018.11.022
中图分类号
O646 [电化学、电解、磁化学];
学科分类号
081704 ;
摘要
Amorphous carbon nitride a-CN0.26 thin films were elaborated on transparent and conductive glass/ indium-tin oxide (ITO) wafers to improve the electroanalytical detection of transthyretin peptide (PN) and specific amino acids (AA) from its sequence, which constitutes a great challenge for the diagnosis of transthyretin-related familial amyloid polyneuropathy (ATTR). The naphthalene-2,3-dicarboxyaldehyde (NDA) label was used for the derivatization reaction of PN and AAs to form N-2-substituted-1-cyanobenz-[f]-isoindole derivatives (CBI) which are both fluorescent and electroactive. The results obtained on a-CN0.26 were compared with those observed on glassy carbon (GC) as a reference material. It was shown that a soft anodic pre-treatment protocol on glass/ITO/a-CN0.26 electrode in a KCI aqueous solution drastically improved the performances of the CBI-PN and CBI-AA oxidation peak. The oxidation peak potential for all CBI derivatives varied in the same range than those measured on GC and pretreated glass/ITO/a-CN0.26, while no discrimination could be obtained on as-grown glass/ITO/a-CN0.26 electrodes. For almost all the tested CBI derivatives, peak areas, full-widths at peak mid-height, peak current density and their standard deviation (SD) values were improved on a pre-treated a-CN0.26 electrode in comparison with GC. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码:251 / 258
页数:8
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