Development of a Glassy Carbon Electrode Modified with Graphene/Au Nanoparticles for Determination of Acetaminophen in Pharmaceutical Preparation

被引：12
|
作者：
Wei, Yingliang [1 ]
Wang, Anting [1 ]
Liu, Yuanyuan [1 ]
机构：
[1] Luoyang Inst Sci & Technol, Sch Environm Engn & Chem, Luoyang 471023, Peoples R China
来源：
RUSSIAN JOURNAL OF ELECTROCHEMISTRY | 2018年 / 54卷 / 12期
关键词：
acetaminophen; grapheme; Au nano-particle; voltammetry; HUMAN PLASMA; PARACETAMOL; OXIDATION;
D O I：
10.1134/S1023193518140112
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
A graphene/Au nanoparticles composite modified glassy carbon electrode (GR/AuNPs/GCE) was developed. Electrochemical behavior of acetaminophen (ACOP) at this modified electrode was studied by liner sweep voltammetry (LSV) in pH 6.0 phosphate buffer solution. The effect factors of the electrochemical response of ACOP were optimized by LSV. Under the optimum conditions, a linear calibration curve of the oxidation peak current of ACOP and concentration was obtained in the range of 1.0 x 10(-6) to similar to 2.2x10(-4) M. The peak current increases linearly with the scan rate, indicating that the reaction of ACOP at the modified electrode is adsorption-controlled process. This new proposed method has been successfully employed to determine acetaminophen in pharmaceutical preparation.
引用
收藏
页码：1141 / 1147
页数：7
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