The role of innate immunity in MDS pathogenesis

被引：2
|
作者：
Sallman, David A. [1 ]
List, Alan [1 ]
机构：
[1] H Lee Moffitt Canc Ctr & Res Inst, Malignant Hematol Dept, Tampa, FL 33612 USA
来源：
HEMASPHERE | 2019年 / 3卷
关键词：
CLONAL HEMATOPOIESIS; LETHAL; CELLS; GENE;
D O I：
10.1097/HS9.0000000000000217
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Take home messages Innate immune activation, driven by MDSC expansion and /or mesenchymal niche cells, may be a disease initiating event in MDS. Cell-extrinsic and-intrinsic signals provoke NLRP3 inflammasome activation that directs an inflammatory cell death, termed pyroptosis, leading to the hallmark pathological features of MDS. Inflammasome activation has potential broad reaching importance as a diagnostic biomarker and therapeutic target in MDS patients.
引用
收藏
页码：135 / 137
页数：3
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