Two New Steroidal Saponins, Hylodoside A and Novaeguinoside Y, from the Starfish Leptasterias hylodes reticulata and Culcita novaeguineae (Juvenile)

被引：0

作者：

Levina, Eleonora V. ^{[1
]}

Kalinovsky, Anatoly I. ^{[1
]}

Dmitrenok, Pavel S. ^{[1
]}

Martyyas, Ekaterina A. ^{[1
]}

Stonik, Valentin A. ^{[1
]}

机构：

[1] Russian Acad Sci, Pacific Inst Bioorgan Chem, Vladivostok 690022, Russia

来源：

NATURAL PRODUCT COMMUNICATIONS | 2010年 / 5卷 / 11期

基金：

俄罗斯基础研究基金会;

关键词：

starfish; asterosaponins; polyhydroxysteroid glycosides; NMR; ESIMS; biological activity;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New steroid glycosides, hylodoside A (1) and novaeguinoside Y (2), along with previously known polyhydroxylated steroids (3-7) were isolated from the ethanolic extracts of the starfish Leptasterias hylodes reticulata and Culcita novaeguineae (juvenile) The structures have been elucidated using ID and 2D NMR spectra ((1)H, (13)C, DEPT, COSY-45, 1D-TOCSY, HSQCGP, ROESY, HSQC and HMBCGP) and mass spectrometry Compound 3 was shown to inhibit the growth of Staphylococcus aureus up to 10% from the control at a concentration of 1 mg/mL Steroids 1, 2 and 5 showed moderate hemolytic activity in the mouse erythrocytes assay Compounds 3 4 and 6 displayed pH-depended hemolytic properties

引用

页码：1737 / 1742

页数：6

共 3 条

[1] Two new polyhydroxylated steroidal glycosides from the starfish Culcita novaeguineae
Lu, Yun-Yang
Wang, Min-Chang
Liu, Ke
Zhang, Wei
Liu, Yang
Tang, Hai-Feng
NATURAL PRODUCT RESEARCH, 2022, 36 (08) : 2118 - 2124
[2] STARFISH SAPONINS .46. STEROIDAL GLYCOSIDES AND POLYHYDROXYSTEROIDS FROM THE STARFISH CULCITA-NOVAEGUINEAE
IORIZZI, M
MINALE, L
RICCIO, R
HIGA, T
TANAKA, J
JOURNAL OF NATURAL PRODUCTS, 1991, 54 (05): : 1254 - 1264
[3] Culcinoside E, a new sulfated steroidal biglycoside from the starfish Culcita novaeguineae
Vien, Le Thi
Hanh, Tran Thi Hong
Quang, Tran Hong
Ngai, Nguyen Dang
Ha, Dao Viet
Cuong, Nguyen Xuan
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2024,

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