Activity-based protein profiling: From enzyme chemistry

被引：947
|
作者：
Cravatt, Benjamin F. [1 ,2 ]
Wright, Aaron T. [1 ,2 ]
Kozarich, John W. [3 ]
机构：
[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA
[3] Activx Biosci, La Jolla, CA 92037 USA
来源：
ANNUAL REVIEW OF BIOCHEMISTRY | 2008年 / 77卷
关键词：
affinity label; mass spectrometry; proteomics;
D O I：
10.1146/annurev.biochem.75.101304.124125
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Genome sequencing projects have provided researchers with a complete inventory of the predicted proteins produced by eukaryotic and prokaryotic organisms. Assignment of functions to these proteins represents one of the principal challenges for the field of proteomics. Activity-based protein profiling (ABPP) has emerged as a powerful chemical proteomic strategy to characterize enzyme function directly in native biological systems on a global scale. Here, we review the basic technology of AMP, the enzyme classes addressable by this method, and the biological discoveries attributable to its application.
引用
收藏
页码：383 / 414
页数：32
相关论文
共 50 条
  • [1] Enzyme Inhibitor Discovery by Activity-Based Protein Profiling
    Niphakis, Micah J.
    Cravatt, Benjamin F.
    ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83, 2014, 83 : 341 - 377
  • [2] Bioorthogonal Chemistry: Applications in Activity-Based Protein Profiling
    Willems, Lianne I.
    Van der Linden, Wouter A.
    Li, Nan
    Li, Kah-Yee
    Liu, Nora
    Hoogendoorn, Sascha
    Van der Marel, Gijs A.
    Florea, Bogdan I.
    Overkleeft, Herman S.
    ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (09) : 718 - 729
  • [3] Activity-based protein profiling: Recent advances in medicinal chemistry
    Deng, Hui
    Lei, Qian
    Wu, Yangping
    He, Yang
    Li, Weimin
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 191
  • [4] Activity-based Protein Profiling
    Wang Chu
    Chen Nan
    ACTA CHIMICA SINICA, 2015, 73 (07) : 657 - 668
  • [5] Application of Activity-Based Protein Profiling to Study Enzyme Function in Adipocytes
    Galmozzi, Andrea
    Dominguez, Eduardo
    Cravatt, Benjamin F.
    Saez, Enrique
    METHODS OF ADIPOSE TISSUE BIOLOGY, PT B, 2014, 538 : 151 - 169
  • [6] Activity-based protein profiling in vivo using click chemistry.
    Speers, AE
    Cravatt, BF
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U185 - U185
  • [7] Chemoselective ligation and activity-based protein profiling assisted by click chemistry
    Ma, LF
    Szardenings, AK
    Cravatt, BF
    Sorensen, EJ
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 227 : U186 - U187
  • [8] Activity-Based Protein Profiling Preface
    Sieber, Stephan
    Nodwell, Matthew
    ACTIVITY-BASED PROTEIN PROFILING, 2012, 324 : IX - X
  • [9] Activity-based protein profiling of microbes
    Sadler, Natalie C.
    Wright, Aaron T.
    CURRENT OPINION IN CHEMICAL BIOLOGY, 2015, 24 : 139 - 144
  • [10] Activity-Based Protein Profiling Preface
    Cravatt, Benjamin F.
    Hsu, Ku-Lung
    Weerapana, Eranthie
    ACTIVITY-BASED PROTEIN PROFILING, 2019, 420 : V - VII
12345