Continuous-flow hydration-condensation reaction: Synthesis of α,β-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid catalyst

被引：40
|
作者：
Rueping, Magnus [1 ]
Bootwicha, Teerawut [1 ]
Baars, Hannah [1 ]
Sugiono, Erli [1 ]
机构：
[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 7卷
基金：
欧洲研究理事会;
关键词：
chalcones; flow reactor; green chemistry; heterogeneous catalysis; microwave; ORGANIC-SYNTHESIS MACOS; ONE-POT SYNTHESIS; COUPLING REACTION; ENANTIOSELECTIVE ADDITION; BIOLOGICAL EVALUATION; CHALCONE DERIVATIVES; AROMATIC-ALDEHYDES; MICROWAVE REACTOR; THIN-FILMS; SCALE-UP;
D O I：
10.3762/bjoc.7.198
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, practical and efficient continuous-flow hydration-condensation protocol was developed for the synthesis of alpha,beta-unsaturated ketones starting from alkynes and aldehydes by employing a heterogeneous catalyst in a flow microwave. The procedure presents a straightforward and convenient access to valuable differently substituted chalcones and can be applied on multigram scale.
引用
收藏
页码：1680 / 1687
页数：8
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