Peptide-Based Subunit Nanovaccines

被引：101

作者：

Skwarczynski, Mariusz ^{[1
]}

Toth, Istvan ^{[1
]}

机构：

[1] Univ Queensland, Sch Chem & Mol Biosci, St Lucia, Qld 4072, Australia

来源：

CURRENT DRUG DELIVERY | 2011年 / 8卷 / 03期

关键词：

Subunit vaccine; peptide epitope; nanotechnology; nanoparticles; infectious diseases; DRUG-DELIVERY SYSTEMS; FUNCTIONALIZED CARBON NANOTUBES; CROSS-LINKED NANOPARTICLES; GROUP-A STREPTOCOCCI; DENDRITIC CELLS; VACCINE DELIVERY; POLY(GAMMA-GLUTAMIC ACID); IMMUNE-RESPONSES; BIODEGRADABLE NANOPARTICLES; BIOMEDICAL APPLICATIONS;

D O I：

10.2174/156720111795256192

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Classical vaccines incorporating live or attenuated microorganisms possess several disadvantages and cannot be applied against cancer and some pathogens. Modern vaccines utilizing immunogenic subunits derived from a particular pathogen are able to overcome these obstacles but need a specific delivery system for their efficacy. Nanotechnology has opened a new window into these delivery methodologies. A nano-sized formulation of subunit vaccines has been proven to be very effective in inducing cellular and humoral immune responses. Here, we review a number of peptide vaccine delivery strategies based on nanoparticles composed of polymers, peptides, lipids, and inorganic materials.

引用

页码：282 / 289

页数：8

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