Differential expression of vascular endothelial growth factor and its receptors in hematopoietic and fatty bone marrow: evidence that neuropilin-1 is produced by fat cells

被引:0
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作者
Belaid, Z
Hubint, F
Humblet, C
Boniver, J
Nusgens, B
Defresne, MP
机构
[1] Univ Liege, Lab Histol Cytol, B-4000 Liege, Belgium
[2] Univ Liege, Lab Anat & Cytol Pathol, B-4000 Liege, Belgium
[3] Univ Liege, Lab Biol Tissus Conjonctifs, B-4000 Liege, Belgium
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中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Vascular endothelial growth factor (VEGF), its receptors (VEGFR-1, VEGFR-2) and neuropillin-1 (NRP-1) are expressed at variable levels in bone marrow. NRP-1 expression is higher in fatty bone marrow than in hematopoietic marrow. Adipocytes are responsible for NRP-1 expression suggesting that they may play a role in hematopoiesis by producing NRP-1 or that NRP-1 may regulate adipocyte activity.
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页码:400 / 401
页数:2
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