Enantiomeric resolution of fluorous mixture by chiral CD columns: asymmetric reduction of a mixture of fluorous ketones

被引：10
|
作者：
Nakamura, Y
Takeuchi, S
Okumura, K
Ohgo, Y
Matsuzawa, H
Mikami, K
机构：
[1] Niigata Univ Pharm & Appl Life Sci, Niigata 9502081, Japan
[2] Tokyo Inst Technol, Dept Appl Chem, Tokyo 1528552, Japan
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 33期
关键词：
D O I：
10.1016/S0040-4039(03)01539-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Asymmetric reduction of a mixture of four fluorous ketone analogues was carried out with (R)-oxazaborolidine as a catalyst. The fluorous mixture products were resolved by a reverse phase HPLC with chiral beta-cyclodextrin column to result in good separation of the enantiomers. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6221 / 6225
页数：5
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