ETV6-NTRK3 induces aggressive acute lymphoblastic leukemia highly sensitive to selective TRK inhibition

被引：54
|
作者：
Roberts, Kathryn G. [1 ]
Janke, Laura J. [1 ]
Zhao, Yaqi [1 ]
Seth, Aman [2 ]
Ma, Jing [1 ]
Finkelstein, David [3 ]
Smith, Steve [4 ]
Ebata, Kevin [4 ]
Tuch, Brian B. [4 ]
Hunger, Stephen P. [5 ,6 ,7 ]
Mullighan, Charles G. [1 ]
机构：
[1] St Jude Childrens Res Hosp, Dept Pathol, 262 Danny Thomas Pl, Memphis, TN 38105 USA
[2] St Jude Childrens Res Hosp, Dept Chem Biol & Therapeut, 332 N Lauderdale St, Memphis, TN 38105 USA
[3] St Jude Childrens Res Hosp, Dept Computat Biol, 332 N Lauderdale St, Memphis, TN 38105 USA
[4] Loxo Oncol, San Francisco, CA USA
[5] Univ Penn, Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA
[6] Univ Penn, Childrens Hosp Philadelphia, Ctr Childhood Res, Philadelphia, PA 19104 USA
[7] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
来源：
BLOOD | 2018年 / 132卷 / 08期
基金：
美国国家卫生研究院;
关键词：
GENE FUSION; KINASE; ETV6; ONCOGENE; EVENT; LINE;
D O I：
10.1182/blood-2018-05-849554
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：861 / 865
页数：5
相关论文
共 50 条
  • [1] Genetic Modeling and Therapeutic Targeting of ETV6-NTRK3 with Loxo-101 in Acute Lymphoblastic Leukemia
    Roberts, Kathryn G.
    Bridges, Olga
    Janke, Laura J.
    Ebata, Kevin
    Tuch, Brian B.
    Nanda, Nisha
    Mullighan, Charles
    BLOOD, 2016, 128 (22)
  • [2] Characterization of a newly identified ETV6-NTRK3 fusion transcript in acute myeloid leukemia
    Kralik, Johanna M.
    Kranewitter, Wolfgang
    Boesmueller, Hans
    Marschon, Renate
    Tschurtschenthaler, Gertraud
    Rumpold, Holger
    Wiesinger, Kurt
    Erdel, Martin
    Petzer, Andreas L.
    Webersinke, Gerald
    DIAGNOSTIC PATHOLOGY, 2011, 6
  • [3] Characterization of a newly identified ETV6-NTRK3 fusion transcript in acute myeloid leukemia
    Johanna M Kralik
    Wolfgang Kranewitter
    Hans Boesmueller
    Renate Marschon
    Gertraud Tschurtschenthaler
    Holger Rumpold
    Kurt Wiesinger
    Martin Erdel
    Andreas L Petzer
    Gerald Webersinke
    Diagnostic Pathology, 6
  • [4] ETV6-NTRK3 - Trk-ing the primary event in human secretory breast cancer
    Euhus, DM
    Timmons, CF
    Tomlinson, GE
    CANCER CELL, 2002, 2 (05) : 347 - 348
  • [5] Pan-Trk Immunoreactivity, ETV6-NTRK3 Fusion Variants and RET Rearrangement in Salivary Secretory Carcinoma
    Yamamoto, Hidetaka
    Nozaki, Yui
    Oda, Yoshinao
    MODERN PATHOLOGY, 2020, 33 (SUPPL 2) : 1241 - 1241
  • [6] Pan-Trk immunohistochemistry reliably identifies ETV6-NTRK3 fusion in secretory carcinoma of the salivary gland
    Bell, Diana
    Ferrarotto, Renata
    Liang, Li
    Goepfert, Ryan P.
    Li, Jie
    Ning, Jing
    Broaddus, Russell
    Weber, Randal S.
    El-Naggar, Adel K.
    VIRCHOWS ARCHIV, 2020, 476 (02) : 295 - 305
  • [7] Targeted therapy using larotrectinib and venetoclax for the relapsed/refractory T-cell acute lymphoblastic leukemia harboring a cryptic ETV6-NTRK3 fusion
    Zhou, Kuangguo
    Gong, Duanhao
    He, Cheng
    Xiao, Min
    Zhang, Meilan
    Huang, Wei
    MOLECULAR CARCINOGENESIS, 2023, 62 (07) : 899 - 906
  • [8] Pan-Trk Immunoreactivity, ETV6-NTRK3 Fusion Variants and RET Rearrangement in Salivary Secretory Carcinoma
    Yamamoto, Hidetaka
    Nozaki, Yui
    Oda, Yoshinao
    LABORATORY INVESTIGATION, 2020, 100 (SUPPL 1) : 1241 - 1241
  • [9] Pan-Trk immunohistochemistry reliably identifies ETV6-NTRK3 fusion in secretory carcinoma of the salivary gland
    Diana Bell
    Renata Ferrarotto
    Li Liang
    Ryan P. Goepfert
    Jie Li
    Jing Ning
    Russell Broaddus
    Randal S. Weber
    Adel K. El-Naggar
    Virchows Archiv, 2020, 476 : 295 - 305
  • [10] An infant with ETV6-NTRK3 fusion-positive congenital infantile fibrosarcoma and delayed response to conventional chemotherapy avoiding the need for TRK inhibition
    Vedi, Aditi
    Holland, Katherine
    Cross, Justin
    Muthusamy, Brinda
    Behjati, Sam
    Hook, C. Elizabeth
    Murray, Matthew J.
    PEDIATRIC BLOOD & CANCER, 2020, 67 (10)
12345