Preparation of new nitrogen-bridged heterocycles. 45. Smooth hydrolysis of 6-membered heterocyclic 2-imines with partial aromaticity

被引：0

作者：

Kakehi, A ^{[1
]}

Ito, S ^{[1
]}

Suga, H ^{[1
]}

Takano, S ^{[1
]}

Hirata, K ^{[1
]}

机构：

[1] Shinshu Univ, Fac Engn, Dept Chem & Mat Engn, Nagano 3808553, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1998年 / 46卷 / 10期

关键词：

2H-thiino[3,2-a]indolizin-2-imine; acidic hydrolysis; X-ray analysis; 2H-thiino[3,2-a]indolizin-2-one; 2H-pyrano[2,3-b]indolizin-2-imine; 2H-pyrano[2,3-b]indolizin-2-one;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The treatment of 2H-pyrano[2,3-b]indolizin-2-imines and 2H-thiino[3,2-a]indolizin-2-imines with acetic acid at reflux temperature smoothly afforded the corresponding 2H-pyrano[2,3-b]indolizin-2-one and 2H-thiino[3,2a]indolizin-2-one derivatives in moderate to good yields. An X-ray analysis of a 2H-thiino[3,2-a]indolizin-2-one derivative was also performed.

引用

页码：1632 / 1634

页数：3

共 12 条

[1] Preparation of new nitrogen-bridged heterocycles. 47. Reactions of 2-indolizinethiolates with acetylenic compounds
Kakehi, A
Ito, S
Suga, H
Takahashi, H
Dobashi, K
HETEROCYCLES, 2000, 52 (01) : 215 - 226
[2] Preparation of new nitrogen-bridged heterocycles. 50. Syntheses of some heterocyclic compounds starting from pyridinium 1-(ethoxycarbonylacetyl)methylides
Kakehi, A
Ito, S
Suga, H
Yasuraoka, K
HETEROCYCLES, 2001, 54 (01) : 185 - 200
[3] PREPARATION OF NEW NITROGEN-BRIDGED HETEROCYCLES. 64. A SMOOTH FORMATION OF 2,4-DIARYLPYRIDO[2,3-b]INDOLIZINE-10-CARBONITRILE DERIVATIVES
Kakehi, Akikazu
Suga, Hiroyuki
Sato, Shuichi
HETEROCYCLES, 2009, 77 (01) : 471 - 481
[4] PREPARATION OF NEW NITROGEN-BRIDGED HETEROCYCLES .5. SMOOTH MICHAEL ADDITIONS OF 2(3H)-INDOLIZINONE DERIVATIVES
KAKEHI, A
ITO, S
WADA, B
WATANABE, K
NISHIMURA, K
KUMAGAI, A
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1982, 55 (11) : 3590 - 3597
[5] PREPARATION OF NEW NITROGEN-BRIDGED HETEROCYCLES. 62.1 REACTION OF POTASSIUM PYRAZOLO[1,5-a]PYRIDINE-2-THIOLATES WITH ELECTRON-POOR ALKYNES
Isawa, Hidetoshi
Kakehi, Akikazu
Suga, Hiroyuki
HETEROCYCLIC COMMUNICATIONS, 2008, 14 (03) : 141 - 148
[6] Preparation of new nitrogen-bridged heterocycles. 48. Syntheses and reactions of ethyl 3-[2-(methylthio)indolizin-3-yl]acrylate derivatives
Kakehi, A
Ito, S
Sa, H
CHEMICAL & PHARMACEUTICAL BULLETIN, 1999, 47 (11) : 1607 - 1613
[7] Preparation of new nitrogen-bridged heterocycles. 55. Reinvestigation of the bromination/dehydrobromination of ethyl 3-[2-(methylthio)indolizin-3-yl]acrylate derivatives
Kakehi, A
Ito, S
Suga, H
Kobayashi, Y
Zuo, P
Iriye, R
CHEMICAL & PHARMACEUTICAL BULLETIN, 2004, 52 (02) : 279 - 281
[8] Preparation of new nitrogen-bridged heterocycles. 56. Syntheses and reactions of 1-[2,2-bis(alkylthio)-1-(ethoxycarbonylacetyl)vinyl]pyridinium salts
Kakehi, A
Suga, H
Yamauchi, Y
Yasuraoka, K
Kobayashi, T
Ohta, A
CHEMICAL & PHARMACEUTICAL BULLETIN, 2004, 52 (11) : 1316 - 1321
[9] PREPARATION OF NEW NITROGEN-BRIDGED HETEROCYCLES .6. 1ST SYNTHESIS OF 2-AROYLFURO[2,3-B]INDOLIZINE DERIVATIVES
KAKEHI, A
ITO, S
OHIZUMI, T
ITO, M
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1983, 56 (04) : 1219 - 1222
[10] PREPARATION OF NEW NITROGEN-BRIDGED HETEROCYCLES .19. SMOOTH SYNTHESES OF THIENO[3,2-A]INDOLIZINE AND THIENO[2,3-B]INDOLIZINE DERIVATIVES
KAKEHI, A
ITO, S
FUJII, T
MORIMOTO, Y
MATSUMOTO, S
SHIOHARA, M
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1989, 62 (01) : 119 - 127

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