CP-945,598, a novel cannabinoid CB1 receptor (CB1 R) antagonist, reduces markers of diabetes by preferentially reducing fat mass

被引：0
|
作者：
Patterson, Terrell A.
Hadcock, John R.
Scott, Dennis O.
Maurer, Tristan
Griffith, David A.
Gibbons, Colleen
Sullivan, Dawn-Kelly
Tomlinson, Elizabeth
机构：
来源：
DIABETES | 2008年 / 57卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：A481 / A481
页数：1
相关论文
共 50 条
  • [1] The Cannabinoid CB1 (CB1) Receptor Antagonist CP-945,598 Dose-Dependently Reduces Body Weight via a Reduction in Fat Mass
    Patterson, Terrell
    Hadcock, John
    Scott, Dennis
    Maurer, Tristan
    Griffith, David
    Gibbons, Colleen
    Kelly-Sullivan, Dawn
    Lizano, Jeffrey
    Tomlinson, Elizabeth
    OBESITY, 2008, 16 : S107 - S107
  • [2] Pharmacological profile of CP-945,598, a potent and selective cannabinoid CB1 receptor antagonist.
    Hadcock, J. R.
    Griffith, D. A.
    Scott, D. O.
    Carpino, P. A.
    DaSilva-Jardines, P.
    Day, R.
    Dibrino, J.
    Dow, R. L.
    Dutcher, D.
    Fichtner, M. W.
    Gautreau, D.
    Iredale, P. A.
    Lizano, J. S.
    O'Connor, R. E.
    Rose, C. R.
    Sakya, S.
    Sands, M. A.
    Swick, A. G.
    Tess, D.
    Ward, K. M.
    Black, S. C.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2008, 83 : S78 - S78
  • [3] STABLE ISOTOPE AND CARBON-14 SYNTHESES OF CP-945,598: A CANNABINOID CB1 RECEPTOR ANTAGONIST
    Garnes, Keith T.
    Schildknegt, Klaas
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2010, 53 (5-6): : 383 - 386
  • [4] Efficacy and Safety of CP-945,598, a Selective Cannabinoid CB1 Receptor Antagonist, on Weight Loss and Maintenance
    Aronne, Louis J.
    Finer, Nick
    Hollander, Priscilla A.
    England, Richard D.
    Klioze, Solomon S.
    Chew, Robert D.
    Fountaine, Robert J.
    Powell, Coralie M.
    Obourn, John D.
    OBESITY, 2011, 19 (07) : 1404 - 1414
  • [5] In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB1 receptor antagonist for the management of obesity
    Hadcock, John R.
    Griffith, David A.
    Iredale, Phillip A.
    Carpino, Phillip A.
    Dow, Robert L.
    Black, Shawn C.
    O'Connor, Rebecca
    Gautreau, Denise
    Lizano, Jeffrey S.
    Ward, Karen
    Hargrove, Diane M.
    Kelly-Sullivan, Dawn
    Scott, Dennis O.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 394 (02) : 366 - 371
  • [6] Pharmacokinetics (PK), Safety, and Tolerability of Multiple Ascending Doses of the Cannabinoid CB1 (CB1) Receptor Antagonist CP-945,598 in Healthy Overweight and Obese Subjects
    Cronenberger, Carol
    Dvorak, Roman
    Venkatakrishnan, Karthik
    Checchio, Tina
    Manganello, Jeanne
    Fountaine, Robert
    Obourn, John
    OBESITY, 2008, 16 : S140 - S140
  • [7] The Cannabinoid CB1 (CB1) Receptor Antagonist, CP-945,598, Does Not Alter the Pharmacokinetics (PK) of a Fixed-Combination Oral Contraceptive (OC) following Once-Daily Administration
    Cronenberger, Carol
    Venkatakrishnan, Karthik
    Checchio, Tina
    Fosser, Cecilia
    Manganello, Jeanne
    Dvorak, Roman
    Obourn, John
    OBESITY, 2008, 16 : S140 - S141
  • [8] Effect of the Cannabinoid CB1 (CB1) Receptor Antagonist, CP-945,598, on the Pharmacokinetics (PK) of the Orally Administered Cytochrome P450 3A (CYP3A) Probe Substrate, Midazolam
    Cronenberger, Carol
    Venkatakrishnan, Karthik
    Sweeney, Kevin
    Mancuso, James
    Manganello, Jeanne
    Dvorak, Roman
    Obourn, John
    OBESITY, 2008, 16 : S140 - S140
  • [9] Development of a Practical and Efficient Synthesis of CP-945,598-01, a CB1 Antagonist for the Treatment of Obesity
    Ragan, John A.
    Bourassa, Dennis E.
    Blunt, Jon
    Breen, Darragh
    Busch, Frank R.
    Cordi, Eric M.
    Damon, David B.
    Do, Nga
    Engtrakul, Alanya
    Lynch, Denis
    McDermott, Ruth E.
    Mongillo, Joseph A.
    O'Sullivan, Maria M.
    Rose, Peter R.
    Vanderplas, Brian C.
    ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2009, 13 (02) : 186 - 197
  • [10] LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation
    Felder, CC
    Joyce, KE
    Briley, EM
    Glass, M
    Mackie, KP
    Fahey, KJ
    Cullinan, GJ
    Hunden, DC
    Johnson, DW
    Chaney, MO
    Koppel, GA
    Brownstein, M
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1998, 284 (01): : 291 - 297
12345