Levels of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 mRNAs in Patients with Primary Hypertension or Hypertension-induced Atherosclerosis

被引:13
|
作者
Su, W. [1 ]
Gao, F. [1 ]
Lu, J. [1 ]
Wu, W. [1 ]
Zhou, G. [1 ]
Lu, S. [1 ]
机构
[1] Nanjing Univ Chinese Med, Wuxi Hosp, Dept Cardiol, Wuxi City 214001, Jiangshu Provin, Peoples R China
关键词
ATHEROSCLEROSIS; HYPERTENSION; MATRIX METALLOPROTEINASE-9; MRNA; TISSUE INHIBITOR OF METALLOPROTEINASE-1; ACUTE MYOCARDIAL-INFARCTION; COLLAGEN TYPE-I; MATRIX METALLOPROTEINASES; BLOOD-PRESSURE; FIBROSIS; EXPRESSION; ARTERIES;
D O I
10.1177/147323001204000317
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
OBJECTIVE: Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) affect degradation of vascular elastin, collagen remodelling and formation of atherosclerotic plaque. This cross-sectional study investigated the levels of MMP-9 and TIMP-1 mRNAs in the blood of patients with primary hypertension with and without hypertension-induced carotid atherosclerosis. METHODS: Hypertensive patients with and without atherosclerosis and age- and gender-matched normotensive subjects were enrolled. MMP-9 and TIMP-1 mRNA were quantified using real-time reverse transcription-polymerase chain reaction. RESULTS: Hypertensive patients (n = 86) had significantly lower levels of TIMP-1 mRNA than normotensive subjects (n = 43). Hypertensive patients with atherosclerosis (n = 42) showed significantly elevated levels of MMP-9 mRNA compared with both normotensive subjects and hypertensive patients without atherosclerosis (n = 44). CONCLUSIONS: Primary hypertension resulted in decreased TIMP-1 mRNA levels, suggesting a potential mechanism contributing to the degradation of elastin. Hypertension-induced atherosclerosis was associated with significantly increased levels of MMP-9 mRNA, which may enhance both the deposition of types I and III collagen and atherosclerotic plaque formation.
引用
收藏
页码:986 / 994
页数:9
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