Neat lipase-catalysed kinetic resolution of racemic 1-phenylethanol and a straightforward modelling of the reaction

被引：8
|
作者：
Varga, Zsofia [1 ]
Kmecz, Ildiko [1 ]
Szecsenyi, Agnes [1 ]
Szekely, Edit [1 ]
机构：
[1] Budapest Univ Technol & Econ, Fac Chem Technol & Biotechnol, Dept Chem & Environm Proc Engn, Budapest, Hungary
来源：
BIOCATALYSIS AND BIOTRANSFORMATION | 2017年 / 35卷 / 06期
基金：
匈牙利科学研究基金会;
关键词：
Kinetic resolution; neat system; ping-pong bi-bi kinetics; activation energy of an enzymatic reaction; free enthalpy difference of an enzymatic reaction; SUPERCRITICAL CARBON-DIOXIDE; CANDIDA-ANTARCTICA; OPTICAL RESOLUTION; ALCOHOLS; TRANSESTERIFICATION; ENANTIOMERS; ACETATE; SOLVENT; SYSTEMS; ESTERS;
D O I：
10.1080/10242422.2017.1360292
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Enzymatic kinetic resolution of racemic 1-phenylethanol catalysed by immobilized Candida antarctica lipase B was investigated in a neat system at the temperature range of 30-70 degrees C. Synthetic triglycerides, namely glycerol triacetate and glycerol tributyrate, were applied as the esterification agents. Both esterification agents were efficient regarding to the enantioselectivity (> 1000). Initial rate of reaction and the kinetic constants were influenced by the applied esterification agent significantly. A detailed modelling approach is presented and verified in the temperature range on 30-60 degrees C for the tributyrin system.
引用
收藏
页码：427 / 433
页数：7
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