Pyridine and pyrimidine functionalized half-sandwich Ru(II)-N heterocyclic carbene complexes: Synthesis, structures, spectra, electrochemistry and biological studies

被引：6

作者：

Rana, Bidyut K. ^{[1
,2
]}

Roymahapatra, Gourisankar ^{[1
]}

Das, Himadri Sekhar ^{[1
]}

Giri, Santanab ^{[1
]}

Cardoso, Marlon H. ^{[3
,4
]}

Franco, Octavio L. ^{[3
,4
]}

Nakka, Kiran K. ^{[5
]}

Santra, Manas K. ^{[5
]}

Bag, Partha Pratim ^{[6
]}

Bertolasi, Valerio ^{[7
,8
]}

Dinda, Joydev ^{[9
]}

机构：

[1] Haldia Inst Technol, Sch Appl Sci & Humanities, Haldia 721657, India

[2] Jadavpur Univ, Dept Chem, Kolkata 700032, India

[3] Univ Catolica Dom Bosco, Programa Posgrad Biotecnol, S Inova Biotech, Campo Grande, MS, Brazil

[4] Univ Catolica Brasilia, Ctr Anal Proteom & Bioquim, Programa Posgrad Ciencias Genom & Biotecnol, Brasilia, DF, Brazil

[5] Natl Ctr Cell Sci, Pune, Maharashtra, India

[6] SRM Univ Sikkim, Sch Basic Sci, Dept Chem, Gangtok 37102, Sikkim, India

[7] Univ Ferrara, Dipartimento Chim, Via L Borsari 46, Ferrara, Italy

[8] Univ Ferrara, Ctr Strutturist Diffrattometr, Via L Borsari 46, Ferrara, Italy

[9] Utkal Univ, Dept Chem, Bhubaneswar 751004, India

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2021年 / 1245卷

关键词：

Ru-NHC; Half-sandwich geometry; Spectra; Electrochemistry; DFT; Cytotoxicity; Molecular docking; RUTHENIUM(II) COMPLEXES; EFFICIENT CATALYSTS; ANTICANCER ACTIVITY; ANTITUMOR-ACTIVITY; METAL-COMPLEXES; PROTEIN-BINDING; GOLD(I); POTENT; DNA; COORDINATION;

D O I：

10.1016/j.molstruc.2021.130939

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

New set of Ru-N-Heterocyclic Carbene (Ru-NHC) complexes 1a and 2a were synthesized from their ligand precursors 1-Methyl-2-pyridin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylium hexafluorophosphate ( 1) and 1Methyl-2-pyrimidin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylium hexafluorophosphate ( 2). The molecules were characterized and their structures were investigated through single crystals X-ray diffraction. The overall coordination around the Ru center can be described as a half-sandwich geometry. Absorption spectra and electrochemical behavior of the complexes were also evaluated, supported by DFT analysis. The complexes were applied on lung (A549), colon (HCT116) and breast (MCF7) cancer cells to examine their in vitro cytotoxicity activity. (c) 2021 Published by Elsevier B.V.

引用

页数：13

共 50 条

[1] Pyridine and pyrimidine functionalized half-sandwich Ru(II)-N heterocyclic carbene complexes: Synthesis, structures, spectra, electrochemistry and biological studies
Rana, Bidyut K.
Roymahapatra, Gourisankar
Das, Himadri Sekhar
Giri, Santanab
Cardoso, Marlon H.
Franco, Octavio L.
Kiran, N. K.
Santra, Manas K.
Bag, Partha Pratim
Bertolasi, Valerio
Dinda, Joydev
JOURNAL OF MOLECULAR STRUCTURE, 2021, 1231
[2] Pyridine and pyrimidine functionalized half-sandwich Ru(II)-N heterocyclic carbene complexes: Synthesis, structures, spectra, electrochemistry and biological studies
Rana, Bidyut K.
Roymahapatra, Gourisankar
Das, Himadri Sekhar
Giri, Santanab
Cardoso, Marlon H.
Franco, Octávio L.
Kiran, N.K.
Santra, Manas K.
Bag, Partha Pratim
Bertolasi, Valerio
Dinda, Joydev
Journal of Molecular Structure, 2021, 1231
[3] Half-sandwich Ru(II) N-heterocyclic carbene complexes in anticancer drug design
Rojas, Oscar A. Lenis
Cordeiro, Sandra
Baptista, Pedro V.
Fernandes, Alexandra R.
JOURNAL OF INORGANIC BIOCHEMISTRY, 2023, 245
[4] Half-sandwich IridiumIII N-heterocyclic carbene antitumor complexes and biological applications
Han, Yali
Tian, Zhenzhen
Zhang, Shumiao
Liu, Xicheng
Li, Juanjuan
Li, Yanru
Liu, Yi
Gao, Min
Liu, Zhe
JOURNAL OF INORGANIC BIOCHEMISTRY, 2018, 189 : 163 - 171
[5] Synthesis and characterization of half-sandwich N-heterocyclic carbene complexes of cobalt and rhodium
Fooladi, E
Dalhus, B
Tilset, M
DALTON TRANSACTIONS, 2004, (22) : 3909 - 3917
[6] Half-sandwich iridium N-heterocyclic carbene anticancer complexes
Wang, Chuanlan
Liu, Jinfeng
Tian, Zhenzhen
Tian, Meng
Tian, Laijin
Zhao, Wenqian
Liu, Zhe
DALTON TRANSACTIONS, 2017, 46 (21) : 6870 - 6883
[7] Catalytic activity of a half-sandwich Ru(II)-N-heterocyclic carbene complex in the oligomerization of alkynes
Csabai, Peter
Joo, Ferenc
Trzeciak, Anna M.
Ziolkowski, Jozef J.
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2006, 691 (15) : 3371 - 3376
[8] Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes
Petrovic, Tamara A.
Dimitrijevic, Marija V.
Mihajlovic-Lalic, Ljiljana E.
Stankovic, Dalibor
Vlahovic, Filip
Grguric-Sipka, Sanja
Mihajilov-Krstev, Tatjana M.
Miladinovic, Dragoljub L.
Poljarevic, Jelena M.
JOURNAL OF COORDINATION CHEMISTRY, 2024, 77 (7-8) : 750 - 765
[9] Cationic Half-Sandwich Iron(II) and Iron(III) Complexes with N-Heterocyclic Carbene Ligands
Cardoso, Joao M. S.
Fernandes, Ana
Cardoso, Bernardo de P.
Carvalho, Maria Deus
Ferreira, Liliana P.
Calhorda, Maria Jose
Royo, Beatriz
ORGANOMETALLICS, 2014, 33 (20) : 5670 - 5677
[10] Half-sandwich Ru(II), Ir(III) and Rh(III) complexes with bridging or chelating N-heterocyclic bis-carbene ligand: Synthesis and characterization
Su, Ge
Huo, Xian-Kuan
Jin, Guo-Xin
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2011, 696 (02) : 533 - 538

← 1 2 3 4 5 →