Cohesin: a global player in chromosome biology with local ties to gene regulation

被引：35

作者：

Merkenschlager, Matthias ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, MRC Clin Sci Ctr, Lymphocyte Dev Grp, London W12 0NN, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2010年 / 20卷 / 05期

基金：

英国医学研究理事会;

关键词：

SISTER-CHROMATID COHESION; DE-LANGE-SYNDROME; ENHANCER-BLOCKING ACTIVITY; BUDDING YEAST CHROMOSOMES; DOUBLE-STRAND BREAKS; CCCTC-BINDING FACTOR; NIPPED-B; HISTONE MODIFICATION; FISSION YEAST; HUMAN HOMOLOG;

D O I：

10.1016/j.gde.2010.05.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cohesin complexes hold sister chromatids together, which is essential for proper chromosome segregation during cell division and for post-replicative DNA repair. Recent studies suggest that, in addition to this global role in chromosome biology, cohesin is recruited to specific chromosomal locations by CTCF, and perhaps by other sequence-specific DNA binding factors. Once in position, cohesin controls chromosome conformation at the local level. Could this be key to understanding cohesin's role in gene expression?

引用

页码：555 / 561

页数：7

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