PD-L1-Expressing Dendritic Cells Contribute to Viral Resistance during Acute HSV-1 Infection

被引:14
|
作者
Bryant-Hudson, Katie M. [1 ]
Carr, Daniel J. J. [1 ]
机构
[1] Univ Oklahoma, Hlth Sci Ctr, Dept Ophthalmol, Dean McGee Eye Inst, Oklahoma City, OK 73104 USA
来源
CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2012年
关键词
HERPETIC STROMAL KERATITIS; CD8(+) T-CELLS; TRIGEMINAL GANGLIA; SIMPLEX VIRUS-1; HIV-INFECTION; EXHAUSTION; TYPE-1; EXPRESSION; LATENCY; PD-1;
D O I
10.1155/2012/924619
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The inhibitory receptor, Programmed Death 1 (PD-1), and its ligands (PD-L1/PD-L2) are thought to play a role in immune surveillance during chronic viral infection. The contribution of the receptor/ligand pair during an acute infection is less understood. To determine the role of PD-L1 and PD-L2 during acute ocular herpes simplex virus type 1 (HSV-1) infection, HSV-1-infected mice administered neutralizing antibody to PD-L1 or PD-L2 were assessed for viral burden and host cellular immune responses. Virus titers were elevated in cornea and trigeminal ganglia (TG) of anti-PD-L1-treated mice which corresponded with a reduced number of CD80-expressing dendritic cells, PD-L1(+) dendritic cells, and HSV-1-specific CD8(+) T cells within the draining (mandibular) lymph node (MLN). In contrast, anti-PD-L2 treatment had no effect on viral replication or changes in the MLN population. Notably, analysis of CD11c-enriched MLN cells from anti-PD-L1-treated mice revealed impaired functional capabilities. These studies indicate PD-L1-expressing dendritic cells are important for antiviral defense during acute HSV-1 infection.
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页数:9
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