Convergent grey and white matter evidence of orbitofrontal cortex changes related to disinhibition in behavioural variant frontotemporal dementia

被引:179
|
作者
Hornberger, Michael [1 ,2 ]
Geng, John [1 ]
Hodges, John R. [1 ,2 ]
机构
[1] Neurosci Res Australia, Sydney, NSW 2031, Australia
[2] Univ New S Wales, Sch Med Sci, Sydney, NSW 2052, Australia
基金
澳大利亚研究理事会;
关键词
behavioural variant frontotemporal dementia; disinhibition; orbitofrontal cortex; voxel-based morphometry; diffusion tensor imaging; MILD ALZHEIMERS-DISEASE; INFERIOR FRONTAL GYRUS; COGNITIVE TEST BATTERY; LOBAR DEGENERATION; PREFRONTAL CORTEX; DOUBLE DISSOCIATION; INHIBITORY CONTROL; EPISODIC MEMORY; STOP-SIGNAL; DYSFUNCTION;
D O I
10.1093/brain/awr173
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Disinhibition is a common behavioural symptom in frontotemporal dementia but its neural correlates are still debated. In the current study, we investigated the grey and white matter neural correlates of disinhibition in a sample of behavioural variant frontotemporal dementia (n = 14) and patients with Alzheimer's disease (n = 15). We employed an objective (Hayling Test of inhibitory functioning) and subjective/carer-based (Neuropsychiatric Inventory) measure of disinhibition to reveal convergent evidence of disinhibitory behaviour. Mean and overlap-based statistical analyses were conducted to investigate profiles of performance in patients with behavioural variant frontotemporal dementia, Alzheimer's disease and controls. Hayling Test and Neuropsychiatric Inventory scores were entered as covariates in a grey matter voxel-based morphometry, as well as in a white matter diffusion tensor imaging analysis to determine the underlying grey and white matter correlates. Patients with behavioural variant frontotemporal dementia showed more disinhibition on both behavioural measures in comparison to patients with Alzheimer's disease and controls. Voxel-based morphometry results revealed that atrophy in orbitofrontal/subgenual, medial prefrontal cortex and anterior temporal lobe areas covaried with total errors score of the Hayling Test. Similarly, the Neuropsychiatric Inventory disinhibition frequency score correlated with atrophy in orbitofrontal cortex and temporal pole brain regions. The orbitofrontal atrophy related to the objective (Hayling Test) and subjective (Neuropsychiatric Inventory) measures of disinhibition was partially overlapping. Diffusion tensor imaging analysis revealed that white matter integrity fractional anisotropy values of the white matter tracts connecting the identified grey matter regions, namely uncinate fasciculus, forceps minor and genu of the corpus callosum, correlated well with the total error score of the Hayling Test. Our results show that a network of orbitofrontal, anterior temporal and mesial frontal brain regions and their connecting white matter tracts are involved in inhibitory functioning. Further, we find convergent evidence for objective and subjective disinhibition measures that the orbitofrontal/subgenual brain region is critical for adapting and maintaining normal behaviour.
引用
收藏
页码:2502 / 2512
页数:11
相关论文
共 50 条
  • [21] Infratentorial pathology in frontotemporal dementia: cerebellar grey and white matter alterations in FTD phenotypes
    Mary Clare McKenna
    Rangariroyashe H. Chipika
    Stacey Li Hi Shing
    Foteini Christidi
    Jasmin Lope
    Mark A. Doherty
    Jennifer C. Hengeveld
    Alice Vajda
    Russell L. McLaughlin
    Orla Hardiman
    Siobhan Hutchinson
    Peter Bede
    Journal of Neurology, 2021, 268 : 4687 - 4697
  • [22] Infratentorial pathology in frontotemporal dementia: cerebellar grey and white matter alterations in FTD phenotypes
    McKenna, Mary Clare
    Chipika, Rangariroyashe H.
    Li Hi Shing, Stacey
    Christidi, Foteini
    Lope, Jasmin
    Doherty, Mark A.
    Hengeveld, Jennifer C.
    Vajda, Alice
    McLaughlin, Russell L.
    Hardiman, Orla
    Hutchinson, Siobhan
    Bede, Peter
    JOURNAL OF NEUROLOGY, 2021, 268 (12) : 4687 - 4697
  • [23] Functional connectivity and microstructural white matter changes in phenocopy frontotemporal dementia
    R. Meijboom
    R. M. E. Steketee
    I. de Koning
    R. J. Osse
    L. C. Jiskoot
    F. J. de Jong
    A. van der Lugt
    J. C. van Swieten
    M. Smits
    European Radiology, 2017, 27 : 1352 - 1360
  • [24] Functional connectivity and microstructural white matter changes in phenocopy frontotemporal dementia
    Meijboom, R.
    Steketee, R. M. E.
    de Koning, I.
    Osse, R. J.
    Jiskoot, L. C.
    de Jong, F. J.
    van der Lugt, A.
    van Swieten, J. C.
    Smits, M.
    EUROPEAN RADIOLOGY, 2017, 27 (04) : 1352 - 1360
  • [25] Evidence of semantic processing impairments in behavioural variant frontotemporal dementia and Parkinson's disease
    Cousins, Katheryn A. Q.
    Grossman, Murray
    CURRENT OPINION IN NEUROLOGY, 2017, 30 (06) : 617 - 622
  • [26] Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease
    Zhou, Juan
    Greicius, Michael D.
    Gennatas, Efstathios D.
    Growdon, Matthew E.
    Jang, Jung Y.
    Rabinovici, Gil D.
    Kramer, Joel H.
    Weiner, Michael
    Miller, Bruce L.
    Seeley, William W.
    BRAIN, 2010, 133 : 1352 - 1367
  • [27] The role of the orbitofrontal cortex in regulation of interpersonal space: evidence from frontal lesion and frontotemporal dementia patients
    Perry, Anat
    Lwi, Sandy J.
    Verstaen, Alice
    Dewar, Callum
    Levenson, Robert W.
    Knight, Robert T.
    SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 2016, 11 (12) : 1894 - 1901
  • [28] The impact of the white matter hyperintensities to the cognitive function in the patients with behavioral variant frontotemporal dementia
    Ku, Bon
    Park, Key Hyung
    Han, Hyun Jung
    Youn, Young Chul
    Yoon, Bora
    Park, Kyung Won
    Lee, Jae-Hong Lee
    Kim, Eun-Joo
    Na, Duk L.
    Park, Key Chung
    DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2012, 33 : 190 - 191
  • [29] White matter hyperintensities are associated with grey matter atrophy and cognitive decline in Alzheimer's disease and frontotemporal dementia
    Dadar, Mahsa
    Manera, Ana Laura
    Ducharme, Simon
    Collins, D. Louis
    NEUROBIOLOGY OF AGING, 2022, 111 : 54 - 63
  • [30] Significant grey matter changes in a region of the orbitofrontal cortex in healthy participants predicts emotional dysregulation
    Petrovic, Predrag
    Ekman, Carl Johan
    Klahr, Johanna
    Tigerstrom, Lars
    Ryden, Goran
    Johansson, Anette G. M.
    Sellgren, Carl
    Golkar, Armita
    Olsson, Andreas
    Ohman, Arne
    Ingvar, Martin
    Landen, Mikael
    SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 2016, 11 (07) : 1041 - 1049