Lanostane triterpenoids and ergostane-type steroids from the cultured mycelia of Ganoderma capense

被引：12
|
作者：
Tan, Zhen [1 ,2 ]
Zhao, Jin-Lian [1 ,2 ]
Liu, Ji-Mei [1 ,2 ]
Zhang, Min [1 ,2 ]
Chen, Ri-Dao [1 ,2 ,3 ]
Xie, Ke-Bo [1 ,2 ,3 ]
Chen, Da-Wei [1 ,2 ,3 ]
Dai, Jun-Gui [1 ,2 ,3 ]
机构：
[1] Chinese Acad Med Sci, Inst Materia Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
[2] Peking Union Med Coll, Beijing 100050, Peoples R China
[3] Chinese Acad Med Sci, Inst Materia Med, Key Lab Biosynth Nat Prod, Natl Hlth & Family Planning Commiss, Beijing 100050, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2018年 / 20卷 / 09期
关键词：
Ganoderma capense; triterpenoids; steroids; cytotoxic activity; COLORIMETRIC ASSAY; LUCIDUM; COMPOUND; GROWTH;
D O I：
10.1080/10286020.2017.1399879
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new lanostane triterpenoids (1 and 2), two new ergostane-type steroids (3 and 4) together with two known lanostane triterpenoids (5 and 6) and one known steroid (7) were isolated from the cultured mycelia of Ganoderma capense (CGMCC 5.71). Their structures were determined on the basis of extensive spectroscopic (HRESIMS, 1D NMR, 2D NMR) data analyses. Compound 1 exhibited moderate cytotoxic activity against the human cancer cell line NCI-H1650 with an IC50 value of 22.3M, and 7 displayed cytotoxic activity against the human cancer cell line HCT116 with an IC50 value of 17.4M. In addition, compounds 2, 3, 5, and 6 displayed weak anti-HIV activity with IC50 values of 23.5, 46.7, 21.6, and 30.1M, respectively. [GRAPHICS] .
引用
收藏
页码：844 / 851
页数：8
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