Recent Advances in Polymeric Nano-sized Carrier Systems

被引:17
|
作者
Zhao, Yu [1 ]
Cao, Wanqing [1 ,2 ]
Liu, Yang [1 ,2 ]
机构
[1] Nankai Univ, Coll Chem, Minist Educ, Key Lab Funct Polymer Mat, Tianjin 300071, Peoples R China
[2] Nankai Univ, Natl Chem Expt Teaching Demonstrat Ctr, Tianjin 300071, Peoples R China
来源
关键词
Nanotechnology; Polymer; Nano-sized carrier system; Targeted drug delivery; Drug controlled release; BLOOD-BRAIN-BARRIER; DRUG-DELIVERY; TUMOR MICROENVIRONMENT; BLOCK-COPOLYMERS; INTRACELLULAR DELIVERY; TARGETED DELIVERY; CIRCULATION TIME; NANOPARTICLES; NANOCAPSULES; EFFICIENT;
D O I
10.7503/cjcu20190646
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In recent years, the nanotechnology has attracted a lot of attention in biomedicine owing to the great enhancement of therapeutic efficiency. A variety of polymeric nano-sized carrier systems have been developed for targeted drug delivery and drug controlled release. In order to improve drug accumulation in the focal lesions and reduce the side effects, smart stimuli.responsive nano-sized carriers have emerged. Now, the poly. meric nano-sized drug carriers have shown great potential for cancers, metabolic disorders and infectious diseases. This review focuses on the recent advances in polymeric nano-sized carriers and their applications in bio-medicine.
引用
收藏
页码:909 / 923
页数:15
相关论文
共 90 条
  • [1] Methotrexate-loaded chitosan nanogels as 'Trojan Horses' for drug delivery to brain: Preparation and in vitro/in vivo characterization
    Azadi, Amir
    Hamidi, Mehrdad
    Rouini, Mohammad-Reza
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2013, 62 : 523 - 530
  • [2] Acetal-derivatized dextran:: An acid-responsive biodegradable material for therapeutic applications
    Bachelder, Eric M.
    Beaudette, Tristan T.
    Broaders, Kyle E.
    Dashe, Jesse
    Frechet, Jean M. J.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (32) : 10494 - +
  • [3] Targeted drug delivery to tumors: Myths, reality and possibility
    Bae, You Han
    Park, Kinam
    [J]. JOURNAL OF CONTROLLED RELEASE, 2011, 153 (03) : 198 - 205
  • [4] Promoting Player Empathy for People Living with Poverty
    Braley, Mollie
    Zhao, Yifei
    Kunhikrishnan, Nisha
    Bofenkamp, Matthew
    Chen, Siyu
    Christel, Michael
    Chiu, Yu-Kai
    Hammer, Jessica
    [J]. CHI PLAY'19: EXTENDED ABSTRACTS OF THE ANNUAL SYMPOSIUM ON COMPUTER-HUMAN INTERACTION IN PLAY, 2019, : 233 - 239
  • [5] A surface-adaptive nanocarrier to prolong circulation time and enhance cellular uptake
    Cheng, Tangjian
    Ma, Rujiang
    Zhang, Yumin
    Ding, Yuxun
    Liu, Jinjian
    Ou, Hanlin
    An, Yingli
    Liu, Jianfeng
    Shi, Linqi
    [J]. CHEMICAL COMMUNICATIONS, 2015, 51 (81) : 14985 - 14988
  • [6] Therapeutic nanoparticles for drug delivery in cancer
    Cho, Kwangjae
    Wang, Xu
    Nie, Shuming
    Chen, Zhuo
    Shin, Dong M.
    [J]. CLINICAL CANCER RESEARCH, 2008, 14 (05) : 1310 - 1316
  • [7] A Semiconducting Polymer Nano-prodrug for Hypoxia-Activated Photodynamic Cancer Therapy
    Cui, Dong
    Huang, Jiaguo
    Zhen, Xu
    Li, Jingchao
    Jiang, Yuyan
    Pu, Kanyi
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 58 (18) : 5920 - 5924
  • [8] The Therapeutics of Alzheimer's Disease: Where We Stand and Where We Are Heading
    Dennis, J.
    Selkoe, M. D.
    [J]. ANNALS OF NEUROLOGY, 2013, 74 (03) : 328 - 336
  • [9] On the Mechanism and Dynamics of Uptake and Permeation of Polyether-Copolyester Dendrimers Across an In Vitro Blood-Brain Barrier Model
    Dhanikula, Renu Singh
    Hammady, Taha
    Hildgen, Patrice
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 98 (10) : 3748 - 3760
  • [10] Emeline R., 2018, CHEM SOC REV, V47, P8572