PRL-3 Phosphatase and Cancer Metastasis

被引:124
|
作者
Al-Aidaroos, Abdul Qader O. [1 ,2 ]
Zeng, Qi [1 ,2 ,3 ]
机构
[1] ASTAR, Inst Mol & Cell Biol, Singapore 138648, Singapore
[2] Natl Univ Singapore, NUS Grad Sch Integrat Sci & Engn, Singapore 117456, Singapore
[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 119260, Singapore
关键词
PRL-3; PHOSPHATASE; CANCER METASTASIS; CANCER CELL SIGNALING; PROTEIN-TYROSINE-PHOSPHATASE; EPITHELIAL-MESENCHYMAL TRANSITION; REGENERATING LIVER; CELL-GROWTH; GENE-EXPRESSION; MONOCLONAL-ANTIBODIES; COLORECTAL-CANCER; TUMOR-METASTASIS; DOWN-REGULATION; LUNG-CANCER;
D O I
10.1002/jcb.22913
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The deregulated expression of members of the phosphatase of regenerating liver (PRL) family has been implicated in the metastatic progression of multiple human cancers. Importantly, PRL-1 and PRL-3 both possess the capacity to drive key steps in metastatic progression. Yet, little is known about the regulation and oncogenic mechanisms of this emerging class of dual-specificity phosphatases. This prospect article details the involvement of PRLs in the metastatic cascade, the regulatory mechanisms controlling PRL expression, and recent efforts in the characterization of PRL-modulated pathways and substrates using biochemical and high-throughput approaches. Current advances and future prospects in anti-cancer therapy targeting this family are also discussed. J. Cell. Biochem. 111: 1087-1098, 2010. (C) 2010 Wiley-Liss, Inc.
引用
收藏
页码:1087 / 1098
页数:12
相关论文
共 50 条
  • [11] Structural insights into molecular function of the metastasis-associated phosphatase PRL-3
    Kozlov, G
    Cheng, J
    Ziomek, E
    Banville, D
    Gehring, K
    Ekiel, I
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (12) : 11882 - 11889
  • [12] PRL-3, a phospbatase implied in cancer metastasis: structure and function
    Innocenti, F
    Sette, M
    Forte, E
    Lo Surdo, P
    Cerretani, M
    Altamura, S
    Tomei, L
    Barbato, G
    PROTEIN SCIENCE, 2004, 13 : 127 - 127
  • [13] Protein Tyrosine Phosphatase PRL-3: A Key Player in Cancer Signaling
    Liu, Haidong
    Li, Xiao
    Shi, Yin
    Ye, Zu
    Cheng, Xiangdong
    BIOMOLECULES, 2024, 14 (03)
  • [14] PCBP1 Suppresses the Translation of Metastasis-Associated PRL-3 Phosphatase
    Wang, Haihe
    Vardy, Leah A.
    Tan, Cheng Peow
    Loo, Jia Min
    Guo, Ke
    Li, Jie
    Lim, Seng Gee
    Zhou, Jianbiao
    Chng, Wee Joo
    Ng, Siok Bian
    Li, Hui Xiang
    Zeng, Qi
    CANCER CELL, 2010, 18 (01) : 52 - 62
  • [15] PRL-3 expression in cancer
    Gao, Xiang
    BIOMEDICINE & PHARMACOTHERAPY, 2008, 62 (07) : 423 - 423
  • [16] Expression of PRL-3 phosphatase in human gastric carcinomas: Close correlation with invasion and metastasis
    Miskad, UA
    Semba, S
    Kato, H
    Yokozaki, H
    PATHOBIOLOGY, 2004, 71 (04) : 176 - 184
  • [17] NOVEL ROLE OF PRL-3 PHOSPHATASE IN HEMATOLOGICAL MALIGNANCIES
    Chong, Phyllis
    Chng, Wee Joo
    Lim, Julia
    Zhou, Jianbiao
    EXPERIMENTAL HEMATOLOGY, 2019, 76 : S67 - S67
  • [18] Phosphatase of regenerating liver-3 (PRL-3) is associated with metastasis and poor prognosis in gastric carcinoma
    Xiaofang Xing
    Shenyi Lian
    Ying Hu
    Ziyu Li
    Lianhai Zhang
    Xianzi Wen
    Hong Du
    Yongning Jia
    Zhixue Zheng
    Lin Meng
    Chengchao Shou
    Jiafu Ji
    Journal of Translational Medicine, 11
  • [19] Targeted Deletion of the Metastasis-Associated Phosphatase Ptp4a3 (PRL-3) Suppresses Murine Colon Cancer
    Zimmerman, Mark W.
    Homanics, Gregg E.
    Lazo, John S.
    PLOS ONE, 2013, 8 (03):
  • [20] Phosphatase of regenerating liver-3 (PRL-3) is associated with metastasis and poor prognosis in gastric carcinoma
    Xing, Xiaofang
    Lian, Shenyi
    Hu, Ying
    Li, Ziyu
    Zhang, Lianhai
    Wen, Xianzi
    Du, Hong
    Jia, Yongning
    Zheng, Zhixue
    Meng, Lin
    Shou, Chengchao
    Ji, Jiafu
    JOURNAL OF TRANSLATIONAL MEDICINE, 2013, 11