Disentangling the manifold functions of RORγt

被引：1
|
作者：
Korn, Thomas [1 ,2 ]
机构：
[1] Tech Univ Munich, Dept Neurol, Klinikum Rechts Isar, Munich, Germany
[2] Munich Cluster Syst Neurol SyNergy, Munich, Germany
来源：
NATURE IMMUNOLOGY | 2017年 / 18卷 / 10期
关键词：
T(H)17 CELL-DIFFERENTIATION; NETWORK;
D O I：
10.1038/ni.3831
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A two-amino-acid substitution in the transcription factor ROR gamma t disrupts its effect in establishing the transcriptional program of T(H)17 cells while leaving its function in the development of thymocytes and lymphoid-tissue-inducer cells largely intact.
引用
收藏
页码：1059 / 1060
页数：2
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