Signaling and regulation of G protein-coupled receptors in airway smooth muscle

被引：0
|
作者：
Billington, CK
Penn, RB [1 ]
机构：
[1] Thomas Jefferson Univ, Jefferson Med Coll, Dept Med, Div Crit Care Pulm Allerg & Immunol Dis, Philadelphia, PA 19107 USA
[2] Thomas Jefferson Univ, Jefferson Med Coll, Kimmel Canc Ctr, Philadelphia, PA 19107 USA
来源：
RESPIRATORY RESEARCH | 2003年 / 4卷 / 02期
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D O I：
暂无
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth muscle (ASM) functions including contraction, growth, and "synthetic" functions that orchestrate airway inflammation and promote remodeling of airway architecture. In this review we provide a comprehensive overview of the GPCRs that have been identified in ASM cells, and discuss the extent to which signaling via these GPCRs has been characterized and linked to distinct ASM functions. In addition, we examine the role of GPCR signaling and its regulation in asthma and asthma treatment, and suggest an integrative model whereby an imbalance of GPCR-derived signals in ASM cells contributes to the asthmatic state.
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页数：23
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