Towards a neurotransmitter-based retinal prosthesis using an inkjet print-head

被引：18
|
作者：
Noolandi, J
Peterman, MC
Huie, P
Lee, C
Blumenkranz, MS
Fishman, HA
机构：
[1] Stanford Univ, Sch Med, Dept Ophthalmol, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Appl Phys, Stanford, CA 94305 USA
[3] Stanford Univ, Dept Chem Engn, Stanford, CA 94305 USA
来源：
BIOMEDICAL MICRODEVICES | 2003年 / 5卷 / 03期
关键词：
retinal prosthesis; neurotransmitters; inkjet printing; age-related macular degeneration; CELLS; RELEASE; CALCIUM;
D O I：
10.1023/A:1025704124504
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Electronic chips that provide a patterned stimulus to cells in the retina may provide a viable treatment for age-related macular degeneration. A surrogate MEMS device, in the form of a print-head from a desktop printer, has been used to eject a pattern of neurotransmitters (bradykinin) onto living rat pheochromocytoma (PC12) cells. Fluorescent calcium imaging was used to measure the patterned stimulation of individual cells. The chemical stimulation of cells by directed microfluidic delivery may have applications in retinal prosthetic devices, and in other prosthetic implants in the nervous system.
引用
收藏
页码：195 / 199
页数：5
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