Human T-cell leukemia virus type I at age 25: A progress report

被引：24
|
作者：
Matsuoka, M
Jeang, KT
机构：
[1] Kyoto Univ, Inst Virus Res, Lab Virus Immunol, Kyoto 606, Japan
[2] NIAID, Mol Microbiol Lab, NIH, Bethesda, MD 20892 USA
来源：
CANCER RESEARCH | 2005年 / 65卷 / 11期
关键词：
D O I：
10.1158/0008-5472.CAN-05-0559
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
It has been 25 years since the discovery of human T-cell leukemia virus type I (HTLV-1) and its role in adult T-cell leukemia. Here, in brief, we review the current state of our understanding of HTLV-1 epidemiology, viral biology, pathogenesis, and treatment. We discuss how HTLV-1 may transform cells through destabilization of cellular genomic integrity and induction of cellular tolerance for chromosomal errors.
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页码：4467 / 4470
页数：4
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