Design, synthesis and evaluation of novel azasugar-based MMP/ADAM inhibitors

被引：14
|
作者：
Moriyama, H
Tsukida, T
Inoue, Y
Kondo, H
Yoshino, K
Nishimura, SI
机构：
[1] Japan Bioind Assoc, Hokkaido Collaborat Ctr, Sapporo, Hokkaido 0010021, Japan
[2] Nippon Organon KK, R&D Labs, Miyakojima Ku, Osaka 5340016, Japan
[3] Hokkaido Univ, Grad Sch Sci, Div Biol Sci, Kita Ku, Sapporo, Hokkaido 0010021, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 16期
关键词：
D O I：
10.1016/S0960-894X(03)00531-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In order to verify whether azasugar would be a useful scaffold for inhibitory activity against metalloproteinases, we synthesized some azasugar-based compounds. As a result, it is clarified that azasugar moiety could function as successful inhibitor of matrix metalloproteinase-1, -3 and -9 and TACE. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2741 / 2744
页数：4
相关论文
共 50 条
  • [1] Azasugar-based MMP/ADAM inhibitors as antipsoriatic agents
    Moriyama, H
    Tsukida, T
    Inoue, Y
    Yokota, K
    Yoshino, K
    Kondo, H
    Miura, N
    Nishimura, S
    JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (08) : 1930 - 1938
  • [2] Structure-activity relationships of azasugar-based MMP/ADAM inhibitors
    Moriyama, H
    Tsukida, T
    Inoue, Y
    Kondo, H
    Yoshino, K
    Nishimura, SI
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (16) : 2737 - 2740
  • [3] Synthesis and biological activity of selective azasugar-based TACE inhibitors
    Tsukida, T
    Moriyama, H
    Inoue, Y
    Kondo, H
    Yoshino, K
    Nishimura, SI
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (06) : 1569 - 1572
  • [4] Design, synthesis and biological activity of azasugar-based CD163 ectodomain shedding inhibitors
    Attia, Mohamed I.
    Timmermann, Meike
    Hoegger, Petra
    Herdeis, Claus
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2007, 2007 (22) : 3669 - 3675
  • [5] Synthesis and evaluation of novel pyridine-based MMP inhibitors
    Cook, GR
    Hayashi, R
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U151 - U151
  • [6] Design, synthesis, and evaluation of sultam hydroxamates as novel MMP inhibitors.
    Cherney, RJ
    Meyer, DT
    Wasserman, ZR
    Hardman, KD
    Liu, RQ
    Covington, MB
    Qian, MX
    Christ, DD
    Trzaskos, JM
    Newton, RC
    Magolda, RL
    Decicco, CP
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 226 : U21 - U21
  • [7] Synthesis and evaluation of novel heterocyclic MMP inhibitors
    Hayashi, Ryuji
    Jin, Xiaomin
    Cook, Gregory R.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (24) : 6864 - 6870
  • [8] Synthesis and evaluation of novel oxazoline MMP inhibitors
    Cook, GR
    Manivannan, E
    Underdahl, T
    Lukacova, V
    Zhang, YF
    Balaz, S
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (19) : 4935 - 4939
  • [9] Synthesis of Azasugar-Sulfonamide conjugates and their Evaluation as Inhibitors of Carbonic Anhydrases: the Azasugar Approach to Selectivity
    Pratesi, Debora
    Sodini, Andrea
    Matassini, Camilla
    Cardona, Francesca
    Angeli, Andrea
    Carta, Fabrizio
    Ferraroni, Marta
    Supuran, Claudiu T.
    Goti, Andrea
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2021, 2021 (18) : 2604 - 2614
  • [10] Synthesis and evaluation of novel heterocyclic MMP inhibitors.
    Cook, GR
    Xu, W
    Manivannan, E
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U958 - U958
12345