Kisspeptin and GPR54: Discovery of a novel pathway in reproduction

被引：61
|
作者：
Seminara, S. B. [1 ]
Crowley, W. F., Jr. [1 ]
机构：
[1] Massachusetts Gen Hosp, Harvard Partners Reprod Sci Ctr, Reprod Endocrine Unit, Boston, MA 02114 USA
来源：
JOURNAL OF NEUROENDOCRINOLOGY | 2008年 / 20卷 / 06期
关键词：
kisspeptin; GPR54; metastin; genetics; hypogonadotrophic hypogonadism;
D O I：
10.1111/j.1365-2826.2008.01731.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In order to find novel modulators of gonadotrophin-releasing hormone (GnRH) secretion, genetic tools were employed in patients with idiopathic hypogonadotrophic hypogonadism (IHH). Mutations in a G-protein coupled receptor, GPR54, were identified, making this receptor a genetic determinant and indisputable gatekeeper of normal reproductive function. This article places these investigations into historical context and reviews some of the new findings relevant to this pathway.
引用
收藏
页码：727 / 731
页数：5
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