The importance of hypoxia in disease pathogenesis and prognosis is gathering increasing clinical significance and having a greater impact on patient management and outcome. Previous efforts to evaluate hypoxia have included the invasive assessment of hypoxia with immunohistologic and histographic oxygen probes. The emergence of new radiotracers has allowed noninvasive assessment of hypoxia, with the most extensively investigated and validated positron emission tomography radiotracer of hypoxia to date being F-18-fluoromisonodazole (F-18-FMISO). This review discusses the relevance and biology of hypoxia in cells and organ systems, and reviews the laboratory and clinical applications of F-18-FMISO in oncology and noncancer disease states.
机构:
Harbin Med Univ, MIRC, Harbin, Heilongjiang, Peoples R China
Harbin Med Univ, Hosp 4, TOF PET CT MR Ctr, Harbin, Heilongjiang, Peoples R ChinaHarbin Med Univ, MIRC, Harbin, Heilongjiang, Peoples R China
Xu, Zuoyu
Li, Xiao-Feng
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Harbin Med Univ, MIRC, Harbin, Heilongjiang, Peoples R China
Harbin Med Univ, Hosp 4, TOF PET CT MR Ctr, Harbin, Heilongjiang, Peoples R ChinaHarbin Med Univ, MIRC, Harbin, Heilongjiang, Peoples R China
Li, Xiao-Feng
Zou, Hongyan
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Harbin Med Univ, MIRC, Harbin, Heilongjiang, Peoples R ChinaHarbin Med Univ, MIRC, Harbin, Heilongjiang, Peoples R China
Zou, Hongyan
Sun, Xilin
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Harbin Med Univ, MIRC, Harbin, Heilongjiang, Peoples R China
Harbin Med Univ, Hosp 4, TOF PET CT MR Ctr, Harbin, Heilongjiang, Peoples R ChinaHarbin Med Univ, MIRC, Harbin, Heilongjiang, Peoples R China
Sun, Xilin
Shen, Baozhong
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Harbin Med Univ, MIRC, Harbin, Heilongjiang, Peoples R China
Harbin Med Univ, Hosp 4, TOF PET CT MR Ctr, Harbin, Heilongjiang, Peoples R ChinaHarbin Med Univ, MIRC, Harbin, Heilongjiang, Peoples R China
机构:
CNIC, Dept Epidemiol Atherothrombosis & Imaging, Madrid, Spain
Icahn Sch Med Mt Sinai, Translat & Mol Imaging Inst, New York, NY 10029 USACNIC, Dept Epidemiol Atherothrombosis & Imaging, Madrid, Spain
Mateo, Jesus
Izquierdo-Garcia, David
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Icahn Sch Med Mt Sinai, Translat & Mol Imaging Inst, New York, NY 10029 USACNIC, Dept Epidemiol Atherothrombosis & Imaging, Madrid, Spain
Izquierdo-Garcia, David
Badimon, Juan J.
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Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USACNIC, Dept Epidemiol Atherothrombosis & Imaging, Madrid, Spain
Badimon, Juan J.
Fayad, Zahi A.
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Icahn Sch Med Mt Sinai, Translat & Mol Imaging Inst, New York, NY 10029 USACNIC, Dept Epidemiol Atherothrombosis & Imaging, Madrid, Spain
Fayad, Zahi A.
Fuster, Valentin
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CNIC, Dept Epidemiol Atherothrombosis & Imaging, Madrid, Spain
Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USACNIC, Dept Epidemiol Atherothrombosis & Imaging, Madrid, Spain