Knoevenagel condensation of aromatic aldehydes with active methylene compounds catalyzed by lipoprotein lipase

被引：56
|
作者：
Ding, Yan [1 ]
Ni, Xiao [2 ]
Gu, Mengjie [1 ]
Li, Shuang [1 ,2 ]
Huang, He [1 ,2 ]
Hu, Yi [1 ,2 ]
机构：
[1] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, Nanjing 210009, Jiangsu, Peoples R China
[2] Nanjing Tech Univ, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Jiangsu, Peoples R China
来源：
CATALYSIS COMMUNICATIONS | 2015年 / 64卷
基金：
美国国家科学基金会;
关键词：
Lipases; Knoevenagel condensation; Aromatic aldehydes; Active methylene compounds; ORGANIC-SOLVENTS; ALDOL REACTION; IONIC LIQUID; PROMISCUITY; BIOCATALYSIS; ENZYMES; SYSTEM; WATER;
D O I：
10.1016/j.catcom.2015.02.007
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A screening of using different lipases to catalyze the Knoevenagel reaction was realized, and lipase lipoprotein (LPL) from Aspergillus niger showed the best catalytic performance. The reaction conditions including solvent, enzyme loading, and temperature were screened to improve the reaction efficiency. Various kinds of substrates were investigated, and almost all the target products were obtained in good to excellent yields (76-98%) with Z configuration exclusively. This procedure provides a novel, green and efficient method for the Knoevenagel condensation of aromatic aldehydes with active methylene compounds. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：101 / 104
页数：4
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