Detection of Chemical Warfare Agent-Related Phenylarsenic Compounds in Marine Biota Samples by LC-HESI/MS/MS

被引：28
|
作者：
Niernikoski, Hanna [1 ]
Soderstrom, Martin [1 ]
Vanninen, Paula [1 ]
机构：
[1] Univ Helsinki, VERIFIN, Finnish Inst Verificat Chem Weap Convent, Dept Chem, POB 55, FI-00014 Helsinki, Finland
来源：
ANALYTICAL CHEMISTRY | 2017年 / 89卷 / 20期
关键词：
MASS-SPECTROMETRY; BALTIC SEA; MUNITIONS;
D O I：
10.1021/acs.analchem.7b03429
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A new method has been developed to determine oxidation products of three chemical waffare agent (CVVA) related phenylarsenic compounds from marine biota samples by a liquid chromatography-heated electrospray ionization/tandem mass spectrometry (LC-HESI/MS/MS). The target chemicals were oxidation products of Adamsite (DM[ox]), Clark I (DPA[ox]), and triphenylarsine (TPA[ox]). Method was validated within the concentration range of 1-5, 0.2-5, and 0.2-5 ng/g for DM[ox], DPA[ox], and TPA[ox], respectively. The method was linear, precise and accurate. Limits of quantification (LOQ) were 2.0, 1.3, and 2.1 ng/g for DM[ox], DPA[ox], and TPA[ox], respectively. A total of ten fish samples and one lobster sample collected from near Swedish coast, Maseskar dumpsite were analyzed. Trace concentrations below LOQ values were detected in three samples and the elemental composition of oxidized form of Clark I and/or 11 was confirmed by LC-HESI/HRMS. To our knowledge, this is the first study that provides the presence of CWA. related chemicals in marine biota samples.
引用
收藏
页码：11129 / 11134
页数：6
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