Distributions of steroid 5α-reductase and 17α-hydroxylase/C17,20-lyase (P450c17) immunoreactivities in rat gastric mucosa

被引：0

作者：

Yokoi, H ^{[1
]}

Tsuruo, Y

Kominami, S

Yamazaki, T

Ishimura, K

机构：

[1] Kagawa Natl Childrens Hosp, Zentsuji 7658501, Japan

[2] Univ Tokushima, Grad Sch, Inst Hlth Biosci, Dept Anat & Cell Biol, Tokushima 7708503, Japan

[3] Wakayama Med Univ, Sch Med, Dept Anat & Cell Biol, Wakayama 6418509, Japan

[4] Hiroshima Univ, Fac Integrated Arts & Sci, Higashihiroshima 7398521, Japan

来源：

ACTA HISTOCHEMICA ET CYTOCHEMICA | 2005年 / 38卷 / 01期

关键词：

steroid; 5; alpha-reductase; P450c17; gastric mucosa; immunohistochemistry;

D O I：

10.1267/ahc.38.61

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We examined the immunohistochemical localization of steroid 5 alpha-reductase type 1 and 17 alpha-hydroxylase/C17,20-lyase (P450c17) in rat gastric mucosa. Immunoreactivity of 5 alpha-reductase was localized in the chief cells and the mucous neck cells. P450c17 immunoreactivity was localized in the parietal cells. Subcellular localizations of both 5 alpha-reductase and P450c17 were on the membrane of endoplasmic reticulum. 1345007 is a key enzyme of androgen biosynthesis, and 5 alpha-reductase has a high affinity for testosterone and catalyzes the conversion of testosterone to its 5 alpha-reduced metabolite. Thus, it is suggested that there is an androgenic metabolic pathway in rat gastric mucosa.

引用

页码：61 / 67

页数：7

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