Survival in HIV-1 patients receiving antiretroviral therapy in Morocco

Background. - The purpose was to study factors associated with the survival of HIV-1 patients receiving antiretroviral therapy in Morocco. Material and method. - This was a retrospective study of a cohort of 182 HIV-1 patients receiving antiretroviral therapy in the department of dermatology venereology at the Military Instruction Hospital Mohamed V in Rabat during the period from 1 January 2006 to 1 January 2017. Death of any cause during the study period was considered to be the result of HIV infection. The log-rank test was used to compare the survival curves based on determinants. The Cox regression model analyzed the determinants of survival since induction of antiretroviral therapy. Results. - The median follow-up time was 4.7 years (IQR: 1.97-8.18). The mortality rate was 75 deaths per 1000 person-years. Advanced clinical stage CDC C (RR: 2.72; CI 95%: 1.33-5.56) and treatment with indinavir (RR: 1.41; CI 95%: 0.77-2.59) were significantly associated with death. Conclusion. - Initiation of antiretroviral therapy in the early stage of the disease and use of less toxic molecules are recommended to reduce mortality. (C) 2018 Elsevier Masson SAS. All rights reserved.