Potent divalent inhibitors with rigid glucose click spacers for Pseudomonas aeruginosa lectin LecA

被引：72

作者：

Pertici, Francesca ^{[1
]}

Pieters, Roland J. ^{[1
]}

机构：

[1] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Med Chem & Chem Biol, NL-3508 TB Utrecht, Netherlands

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 33期

关键词：

BACTERIAL LECTIN; STRUCTURAL BASIS; HIGH-AFFINITY; MULTIVALENT; RECOGNITION; BINDING; PENTAVALENT; DENDRIMERS; PROSTATE; LIGANDS;

D O I：

10.1039/c2cc30234a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of a new rigid spacer based on carbohydrate-triazole repeating units and their incorporation into divalent systems is described. Inhibition studies showed that a well-matched system with a rigid spacer with flexible ends leads to the most potent inhibition of Pseudomonas aeruginosa lectin LecA.

引用

页码：4008 / 4010

页数：3

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