A synthetic and in silico study on the highly regioselective Diels-Alder reaction of the polyenic antifungal antibiotics natamycin and flavofungin

被引：3

作者：

Fejes, Zsolt ^{[2
]}

Mandi, Attila ^{[3
,4
]}

Komaromi, Istvan ^{[1
]}

Majoros, Laszlo ^{[5
]}

Batta, Gyula ^{[4
]}

Herczegh, Pal ^{[2
]}

机构：

[1] Univ Debrecen, Hungarian Acad Sci, Haemostasis Thrombosis & Vasc Biol Res Grp, H-4032 Debrecen, Hungary

[2] Univ Debrecen, Dept Pharmaceut Chem, H-4032 Debrecen, Hungary

[3] Univ Debrecen, Hungarian Acad Sci, Res Grp Carbohydrates, H-4032 Debrecen, Hungary

[4] Univ Debrecen, Dept Organ Chem, H-4032 Debrecen, Hungary

[5] Univ Debrecen, Dept Med Microbiol, H-4032 Debrecen, Hungary

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 38期

关键词：

D O I：

10.1016/j.tetlet.2010.07.049

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The tetraenic macrolide antibiotic natamycin and the pentaenic macrolide flavofungin gave monoadducts on Diels-Alder reaction with 4-phenyl-1,2,4-triazoline-3,5-dione. The regioselectivity of the reaction as well as the conformation of the products was studied using theoretical calculations. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4968 / 4971

页数：4

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