Asymmetric alkylation of tert-butyl glycinate Schiff base with chiral quaternary ammonium salt under micellar conditions

被引：48
|
作者：
Okino, T [1 ]
Takemoto, Y [1 ]
机构：
[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Dept Chem, Sakyo Ku, Kyoto 6068501, Japan
来源：
ORGANIC LETTERS | 2001年 / 3卷 / 10期
关键词：
D O I：
10.1021/ol015829c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The asymmetric alkylation of the tert-butyl glycinate-benzophenone Schiff base 1 with various arylmethyl bromides catalyzed by O-allyl-N-(9 anthracenylmethyl)cinchonidinium bromide (2) proceeded smoothly under micellar conditions (5 equiv of 1 M KOH and 0.4 equiv of Triton X-100) to give the alkylated products in good yields and with good enantioselectivity (72-85% ee), depending on the electrophiles.
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收藏
页码：1515 / 1517
页数：3
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