Phosphate wasting disorders in adults

被引：28

作者：

Marcucci, G. ^{[1
]}

Masi, L. ^{[1
]}

Ferrari, S. ^{[2
,3
]}

Haffner, D. ^{[4
]}

Javaid, M. K. ^{[5
]}

Kamenicky, P. ^{[6
]}

Reginster, J. -Y. ^{[7
]}

Rizzoli, R. ^{[2
,3
]}

Brandi, M. L. ^{[1
]}

机构：

[1] Univ Florence, Dept Surg & Translat Med, Metab Bone Dis Unit, Florence, Italy

[2] Geneva Univ Hosp, Div Bone Dis, Geneva, Switzerland

[3] Fac Med, Geneva, Switzerland

[4] Hannover Med Sch, Dept Pediat Kidney Liver & Metab Dis, Hannover, Germany

[5] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England

[6] Hop Bicetre, AP HP, Serv Endocrinol & Malad Reprod, Ctr Reference Malad Rares Metab Calcium & Phospho, F-94275 Le Kremlin Bicetre, France

[7] Univ Liege, Dept Publ Hlth Epidemiol & Hlth Econ, Liege, Belgium

来源：

OSTEOPOROSIS INTERNATIONAL | 2018年 / 29卷 / 11期

关键词：

FGF-23; Hypophosphatemia; Osteomalacia; Phosphate wasting disorders; Rickets; Treatment; FIBROBLAST GROWTH FACTOR-23; LINKED HYPOPHOSPHATEMIC RICKETS; TUMOR-INDUCED OSTEOMALACIA; VITAMIN-D-RECEPTOR; HORMONE TREATMENT; PARATHYROID-HORMONE; PRIMARY HYPERPARATHYROIDISM; FIBROUS DYSPLASIA; SERUM PHOSPHORUS; SHORT CHILDREN;

D O I：

10.1007/s00198-018-4618-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A cause of hypophosphatemia is phosphate wasting disorders. Knowledge concerning mechanisms involved in phosphate wasting disorders has greatly increased in the last decade by the identification of phosphatonins, among them FGF-23. FGF-23 is a primarily bone derived factor decreasing renal tubular reabsorption of phosphate and the synthesis of calcitriol. Currently, pharmacological treatment of these disorders offers limited efficacy and is potentially associated to gastrointestinal, renal, and parathyroid complications; therefore, efforts have been directed toward newer pharmacological strategies that target the FGF-23 pathway. This review focuses on phosphate metabolism, its main regulators, and phosphate wasting disorders in adults, highlighting the main issues related to diagnosis and current and new potential treatments.

引用

页码：2369 / 2387

页数：19

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