Structure-based modeling of protein: DNA specificity

被引：13
|
作者：
Joyce, Adam P.
Zhang, Chi
Bradley, Philip
Havranek, James J.
机构：
[1] Campus Box 8232, 4566 Scott Avenue, St. Louis, 63110, MO
来源：
BRIEFINGS IN FUNCTIONAL GENOMICS | 2015年 / 14卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Protein: DNA interactions; Molecular modeling; Binding specificity; Structure prediction; Structural modeling; Transcription factor binding sites; BINDING-SPECIFICITY; PREDICTION; RECOGNITION; DESIGN; MUTATIONS; DOCKING; WATER; PLASTICITY; AFFINITY; DATABASE;
D O I：
10.1093/bfgp/elu044
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Protein: DNA interactions are essential to a range of processes that maintain and express the information encoded in the genome. Structural modeling is an approach that aims to understand these interactions at the physicochemical level. It has been proposed that structural modeling can lead to deeper understanding of the mechanisms of protein: DNA interactions, and that progress in this field can not only help to rationalize the observed specificities of DNA-binding proteins but also to allow researchers to engineer novel DNA site specificities. In this review we discuss recent developments in the structural description of protein: DNA interactions and specificity, as well as the challenges facing the field in the future.
引用
收藏
页码：39 / 49
页数：11
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