Langendorff-Isolated Rat Heart after Acute Experimental Myocardial Infarction

被引：0
|
作者：
Kuptsova, A. M. [1 ]
Bugrov, R. K. [1 ]
Ziyatdinova, N., I [1 ]
Zefirov, T. L. [1 ]
机构：
[1] Kazan Volga Reg State Univ, Dept Human Hlth Protect, Kazan, Republic Of Tat, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2022年 / 173卷 / 06期
基金：
俄罗斯科学基金会;
关键词：
myocardial infarction model; isolated heart; rat;
D O I：
10.1007/s10517-022-05623-y
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
A comparative analysis of functioning of Langendorff-isolated heart from intact rats, sham-operated rats, and rats with a model of myocardial infarction one day after ligation of the left coronary artery was carried out. No significant differences in inotropic and chronotropic functions of the heart were found in the groups of intact and sham-operated animals. In the group of rats with the myocardial infarction model, an increase in HR and a decrease in the maximum contraction and relaxation rates and left-ventricular developed pressure were shown in comparison with the groups of intact and sham-operated animals. At the same time, in the group of sham-operated animals, a decrease in coronary flow and temporal parameters of contraction was observed.
引用
收藏
页码：719 / 722
页数：4
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